IRF4 (Phospho-Tyr122/125)

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

Interferon Regulatory Factor 4

Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).

Defense response to protozoanISS:UniProtKB
Histone H3 acetylationIEA:Ensembl
Histone H4 acetylationIEA:Ensembl
Immune system processManual Assertion Based On ExperimentIBA:GO_Central
Myeloid dendritic cell differentiationIEA:Ensembl
Negative regulation of toll-like receptor signaling pathwayIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of DNA bindingIEA:Ensembl
Positive regulation of interleukin-10 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-13 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-2 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-4 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of T-helper cell differentiation1 PublicationNAS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
T cell activation1 PublicationNAS:UniProtKB
T-helper 17 cell lineage commitmentISS:UniProtKB

Nucleus

Multiple myeloma (MM):
A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia.

Phosphorylation by ROCK2 regulates IL-17 and IL-21 production.