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Rabbit Anti-IRF4 (Phospho-Tyr122/125) Recombinant Antibody (A657) (CBMAB-AP15316LY)

The product is antibody recognizes IRF4 (Phospho-Tyr122/125). The antibody A657 immunoassay techniques such as: WB.
See all IRF4 (Phospho-Tyr122/125) antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
A657
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Interferon Regulatory Factor 4
Introduction
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
Entrez Gene ID
Human3662
Mouse16364
Rat291100
UniProt ID
HumanQ15306
MouseQ64287
RatD3ZEX6
Alternative Names
Interferon Regulatory Factor 4
Function
Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).
Biological Process
Defense response to protozoanISS:UniProtKB
Histone H3 acetylationIEA:Ensembl
Histone H4 acetylationIEA:Ensembl
Immune system processManual Assertion Based On ExperimentIBA:GO_Central
Myeloid dendritic cell differentiationIEA:Ensembl
Negative regulation of toll-like receptor signaling pathwayIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of DNA bindingIEA:Ensembl
Positive regulation of interleukin-10 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-13 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-2 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-4 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of T-helper cell differentiation1 PublicationNAS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
T cell activation1 PublicationNAS:UniProtKB
T-helper 17 cell lineage commitmentISS:UniProtKB
Cellular Location
Nucleus
Involvement in disease
Multiple myeloma (MM):
A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia.
PTM
Phosphorylation by ROCK2 regulates IL-17 and IL-21 production.

He, S., Ding, H., Chen, L., Shen, Y., Liu, Y., Zhu, F., ... & Zuo, J. (2023). Repression of interferon regulatory factor-4 (IRF4) hyperactivation restricts murine lupus. Signal Transduction and Targeted Therapy, 8(1), 188.

Song, J., Ke, B., Tu, W., & Fang, X. (2023). Roles of interferon regulatory factor 4 in the AKI-CKD transition, glomerular diseases and kidney allograft rejection. Renal Failure, 45(2), 2259228.

Hu, L., Li, S., Li, H., Lai, B., & Wen, H. (2022). Interferon regulatory factor 4 (IRF4) promotes lipopolysaccharide-induced colonic mucosal epithelial cell proliferation by regulating macrophage polarization. European Surgical Research, 63(4), 257-268.

Harberts, A., Schmidt, C., Schmid, J., Reimers, D., Koch-Nolte, F., Mittrücker, H. W., & Raczkowski, F. (2021). Interferon regulatory factor 4 controls effector functions of CD8+ memory T cells. Proceedings of the National Academy of Sciences, 118(16), e2014553118.

Sasaki, K., Terker, A. S., Pan, Y., Li, Z., Cao, S., Wang, Y., ... & Harris, R. C. (2021). Deletion of myeloid interferon regulatory factor 4 (Irf4) in mouse model protects against kidney fibrosis after ischemic injury by decreased macrophage recruitment and activation. Journal of the American Society of Nephrology: JASN, 32(5), 1037.

Li, X., Zhai, S., Zhang, J., Zhang, D., Wang, S., Wang, L., & Yu, J. (2021). Interferon regulatory factor 4 correlated with immune cells infiltration could predict prognosis for patients with lung adenocarcinoma. Frontiers in oncology, 11, 698465.

Rauch, D. A., Olson, S. L., Harding, J. C., Sundaramoorthi, H., Kim, Y., Zhou, T., ... & Ratner, L. (2020). Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma. Retrovirology, 17(1), 1-10.

Stilwell, J. M., & Rissi, D. R. (2018). Immunohistochemical labeling of multiple myeloma oncogene 1/interferon regulatory factor 4 (MUM1/IRF-4) in canine cutaneous histiocytoma.

García-Morato, M. B., Santos, F. J. A., Briones, A. C., Moreno, A. B., del Pozo Mate, A., Dominguez-Soto, A., ... & Pena, R. R. (2018). New human combined immunodeficiency caused by interferon regulatory factor 4 (IRF4) deficiency inherited by uniparental isodisomy. Journal of Allergy and Clinical Immunology, 141(5), 1924-1927.

Cherian, M. A., Olson, S., Sundaramoorthi, H., Cates, K., Cheng, X., Harding, J., ... & Rauch, D. (2018). An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia. Journal of Biological Chemistry, 293(18), 6844-6858.

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For research use only. Not intended for any clinical use.

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