ITGAL
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.
Full Name
Integrin Subunit Alpha L
Alternative Names
Integrin Subunit Alpha L
Function
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364).
Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055).
Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110).
Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992).
Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity).
Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055).
Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110).
Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992).
Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity).
Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Biological Process
Cell adhesion1 PublicationNAS:UniProtKB
Cell-cell adhesionBy SimilarityISS:BHF-UCL
Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIMP:BHF-UCL
Inflammatory response1 PublicationNAS:UniProtKB
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Leukocyte cell-cell adhesionManual Assertion Based On ExperimentIMP:ARUK-UCL
Memory T cell extravasationManual Assertion Based On ExperimentIDA:ARUK-UCL
PhagocytosisIEA:UniProtKB-KW
Receptor clusteringManual Assertion Based On ExperimentIMP:UniProtKB
Signal transduction1 PublicationNAS:UniProtKB
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellManual Assertion Based On ExperimentIMP:BHF-UCL
Cell-cell adhesionBy SimilarityISS:BHF-UCL
Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIMP:BHF-UCL
Inflammatory response1 PublicationNAS:UniProtKB
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Leukocyte cell-cell adhesionManual Assertion Based On ExperimentIMP:ARUK-UCL
Memory T cell extravasationManual Assertion Based On ExperimentIDA:ARUK-UCL
PhagocytosisIEA:UniProtKB-KW
Receptor clusteringManual Assertion Based On ExperimentIMP:UniProtKB
Signal transduction1 PublicationNAS:UniProtKB
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 26-1090
Helical: 1091-1111
Cytoplasmic: 1112-1170
Helical: 1091-1111
Cytoplasmic: 1112-1170
PTM
In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.
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Anti-ITGAL antibodies
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CompareTarget: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Hamster, Rabbit
Clone: TS1/22
Application*: B, E, F
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: I21/7
Application*: F, IH, IP, C, BL, N, IC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7H117
Application*: C, WB
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MHM.24
Application*: WB
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: AG119
Application*: F
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: AG118
Application*: F, WB
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: AG117
Application*: F, WB
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A679
Application*: FC
Target: ITGAL
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: A678
Application*: FC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 564
Application*: ELISA, IHC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CAP1040
Application*: FC, ICC, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NKI(SPV)-L7
Application*: FC, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: NKI(SPV)-L16
Application*: FC, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CAP908
Application*: FC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: BU85
Application*: IHC
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: A677
Application*: FC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF248
Application*: ELISA, IHC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB282
Application*: IF, FC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB281
Application*: IF, FC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB280
Application*: IF, FC
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: MAB0812
Application*: B
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NKI SPV-L1
Application*: IF/IC, IP, F
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: YTH81.5
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: R7.1
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: WT.1
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: NKISPV-L15
Application*: WB, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0158
Application*: F, C, FN, IA, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NKI-SPV-L7
Application*: IP, FC, FN, IF
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: NKI-SPV-L15
Application*: FC, IP, WB
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NKI-SPV-L1
Application*: IH, IP, FC, IF
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D247
Application*: FC, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F13
Application*: FC, IF, IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Horse, Rabbit, Sheep
Clone: 3H934
Application*: FC, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 13H37
Application*: FC, IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: OFYS
Application*: FC
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBWJC-3874
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-3872
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3871
Application*: F, IF, IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3870
Application*: F, IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3869
Application*: F, IP
Target: ITGAL
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: IBL-6/2
Application*: C, IP, F
Target: ITGAL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-2231
Application*: F, B, MC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Dog, Rabbit
Clone: HI111
Application*: F, C
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJC-2230
Application*: F
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBWJC-2229
Application*: F
Target: ITGAL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBWJC-2228
Application*: WB, IP, P, C, F, IC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Horse
Clone: CVS9
Application*: F, C
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle, Pig, Sheep
Clone: BL1H8
Application*: F, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: BU85
Application*: IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BU17
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-83
Application*: F, IP, FN
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXC-2620
Application*: IC
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBXC-1547
Application*: F, IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rabbit
Clone: CBXC-1662
Application*: F, IH
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBXC-1626
Application*: F, IH, IP, WB
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1598
Application*: F, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-25
Application*: F
Target: ITGAL
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0831
Application*: F
Target: ITGAL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: hu1124 (Efalizumab)
Application*: F, N, MC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rabbit
Clone: CBYY-C2601
Application*: F, IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2600
Application*: F, IH, IP
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-C0198
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C0196
Application*: F, IH, IP, N
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog
Clone: CBFYC-2814
Application*: F, IH, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-2813
Application*: WB, IF
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-2812
Application*: F, IF, IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-2811
Application*: F, IH, IP
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-0543
Application*: F, IH, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Goat, Sheep
Clone: CBFYC-0187
Application*: F, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1593
Application*: F, IF, C
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0851
Application*: F
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0498
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBYY-I0493
Application*: F, IH, IP, C
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0479
Application*: F, E
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0382
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0319
Application*: F, IP, FN, MC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0317
Application*: BL, F, FN, IP, N, MC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I0268
Application*: E, F, IF, C, IP
Target: ITGAL
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-I0267
Application*: F, C, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: DF1524
Application*: IF, F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CRIS-3
Application*: E, F, FN, IF, C, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog
Clone: CA11.4D3
Application*: F, IH, C
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I0026
Application*: F, IF
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CR38
Application*: F, MC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0015
Application*: F, IH, C, FN, WB, IF, E
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8H155
Application*: C, WB
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 87-6F9
Application*: F, C
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 8-6.2
Application*: F
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 5K221
Application*: F, IH, IP, WB
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5K215
Application*: F, IH, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 27/CD11a
Application*: WB, IF
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 14J11
Application*: F, IF, IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 122
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Horse
Clone: 10B593
Application*: F, IH
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10B584
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cat
Clone: 10B577
Application*: F, IH, IP
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 3H945
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: 3H942
Application*: F, IH, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3H941
Application*: F, IH, IP
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 2D7
Application*: F
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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