Rat Anti-ITGAL Recombinant Antibody (A678) (CBMAB-AP15772LY)

Name: Rat Anti-ITGAL Recombinant Antibody (A678)
SKU: CBMAB-AP15772LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

A678

Application

Specificity

Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Integrin Subunit Alpha L

Introduction

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

16408

UniProt ID

P24063

Alternative Names

Integrin Subunit Alpha L

Function

E-AB-1319

Biological Process

Cell adhesion1 PublicationNAS:UniProtKB
Cell-cell adhesionBy SimilarityISS:BHF-UCL
Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIMP:BHF-UCL
Inflammatory response1 PublicationNAS:UniProtKB
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Leukocyte cell-cell adhesionManual Assertion Based On ExperimentIMP:ARUK-UCL
Memory T cell extravasationManual Assertion Based On ExperimentIDA:ARUK-UCL
PhagocytosisIEA:UniProtKB-KW
Receptor clusteringManual Assertion Based On ExperimentIMP:UniProtKB
Signal transduction1 PublicationNAS:UniProtKB
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Cell membrane

Topology

Extracellular: 26-1090
Helical: 1091-1111
Cytoplasmic: 1112-1170

PTM

In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.

Deng, T., Wang, C., Gao, C., Zhang, Q., & Guo, J. (2023). ITGAL as a prognostic biomarker correlated with immune infiltrates in melanoma. Frontiers in Oncology, 13, 1181537.

Wang, Q., Xiao, G., Li, N., Jiang, X., & Li, C. (2023). lncRNA PCBP1-AS1 mediated downregulation of ITGAL as a prognostic biomarker in lung adenocarcinoma. Aging (Albany NY), 15(10), 4510.

Zhang, J., Wang, H., Yuan, C., Wu, J., Xu, J., Chen, S., ... & He, Y. (2022). ITGAL as a prognostic biomarker correlated with immune infiltrates in gastric cancer. Frontiers in Cell and Developmental Biology, 10, 808212.

De Andrade Costa, A., Chatterjee, J., Cobb, O., Sanapala, S., Scheaffer, S., Guo, X., ... & Gutmann, D. H. (2022). RNA sequence analysis reveals ITGAL/CD11A as a stromal regulator of murine low-grade glioma growth. Neuro-oncology, 24(1), 14-26.

Zhu, X., Liu, B., Ruan, Z., Chen, M., Li, C., Shi, H., ... & Dong, J. (2022). TMT-Based Quantitative Proteomic Analysis Reveals Downregulation of ITGAL and Syk by the Effects of Cycloastragenol in OVA-Induced Asthmatic Mice. Oxidative Medicine and Cellular Longevity, 2022.

Li, R., Wu, X., Xue, K., & Li, J. (2022). ITGAL infers adverse prognosis and correlates with immunity in acute myeloid leukemia. Cancer Cell International, 22(1), 1-11.

Yang, H., Graham, L. C., Reagan, A. M., Grabowska, W. A., Schott, W. H., & Howell, G. R. (2019). Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity. Journal of Neuroinflammation, 16(1), 1-18.

Zhang, J., Teh, M., Kim, J., Eva, M. M., Cayrol, R., Meade, R., ... & Jaubert, J. (2019). A loss-of-function mutation in the integrin alpha l (itgal) gene contributes to susceptibility to salmonella enterica serovar typhimurium infection in collaborative cross strain cc042. Infection and immunity, 88(1), 10-1128.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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