Mouse Anti-ITGAL Antibody (MHM.24) (CBMAB-0001-YC)

Name: Mouse Anti-ITGAL Antibody (MHM.24)
SKU: CBMAB-0001-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

MHM.24

Application

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Integrin Subunit Alpha L

Introduction

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab.

Entrez Gene ID

3683

UniProt ID

P20701

Alternative Names

CD11A; LFA-1; LFA1A

Function

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364).
Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055).
Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110).
Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992).
Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity).
Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).

Biological Process

Cell adhesion1 PublicationNAS:UniProtKB
Cell-cell adhesionBy SimilarityISS:BHF-UCL
Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIMP:BHF-UCL
Inflammatory response1 PublicationNAS:UniProtKB
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Leukocyte cell-cell adhesionManual Assertion Based On ExperimentIMP:ARUK-UCL
Memory T cell extravasationManual Assertion Based On ExperimentIDA:ARUK-UCL
PhagocytosisIEA:UniProtKB-KW
Receptor clusteringManual Assertion Based On ExperimentIMP:UniProtKB
Signal transduction1 PublicationNAS:UniProtKB
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Cell membrane

Topology

Extracellular: 26-1090
Helical: 1091-1111
Cytoplasmic: 1112-1170

PTM

In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.

Deng, T., Wang, C., Gao, C., Zhang, Q., & Guo, J. (2023). ITGAL as a prognostic biomarker correlated with immune infiltrates in melanoma. Frontiers in Oncology, 13, 1181537.

Wang, Q., Xiao, G., Li, N., Jiang, X., & Li, C. (2023). lncRNA PCBP1-AS1 mediated downregulation of ITGAL as a prognostic biomarker in lung adenocarcinoma. Aging (Albany NY), 15(10), 4510.

Zhang, J., Wang, H., Yuan, C., Wu, J., Xu, J., Chen, S., ... & He, Y. (2022). ITGAL as a prognostic biomarker correlated with immune infiltrates in gastric cancer. Frontiers in Cell and Developmental Biology, 10, 808212.

De Andrade Costa, A., Chatterjee, J., Cobb, O., Sanapala, S., Scheaffer, S., Guo, X., ... & Gutmann, D. H. (2022). RNA sequence analysis reveals ITGAL/CD11A as a stromal regulator of murine low-grade glioma growth. Neuro-oncology, 24(1), 14-26.

Zhu, X., Liu, B., Ruan, Z., Chen, M., Li, C., Shi, H., ... & Dong, J. (2022). TMT-Based Quantitative Proteomic Analysis Reveals Downregulation of ITGAL and Syk by the Effects of Cycloastragenol in OVA-Induced Asthmatic Mice. Oxidative Medicine and Cellular Longevity, 2022.

Li, R., Wu, X., Xue, K., & Li, J. (2022). ITGAL infers adverse prognosis and correlates with immunity in acute myeloid leukemia. Cancer Cell International, 22(1), 1-11.

Yang, H., Graham, L. C., Reagan, A. M., Grabowska, W. A., Schott, W. H., & Howell, G. R. (2019). Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity. Journal of Neuroinflammation, 16(1), 1-18.

Zhang, J., Teh, M., Kim, J., Eva, M. M., Cayrol, R., Meade, R., ... & Jaubert, J. (2019). A loss-of-function mutation in the integrin alpha l (itgal) gene contributes to susceptibility to salmonella enterica serovar typhimurium infection in collaborative cross strain cc042. Infection and immunity, 88(1), 10-1128.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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