ITGB6

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Full Name

Integrin Subunit Beta 6

Function

Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17545607, PubMed:17158881).
It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881).
Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17545607, PubMed:17158881).
ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881).
Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447).
(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1.
(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260).

Biological Process

Bone developmentIEA:Ensembl
Bronchiole developmentIEA:Ensembl
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesion mediated by integrinManual Assertion Based On ExperimentIDA:UniProtKB
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Cell morphogenesisIEA:Ensembl
Cell-matrix adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to ionizing radiationIEA:Ensembl
Enamel mineralizationIEA:Ensembl
Hard palate developmentIEA:Ensembl
Immune responseIEA:Ensembl
Inflammatory responseIEA:Ensembl
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Langerhans cell differentiationIEA:Ensembl
Lung alveolus developmentIEA:Ensembl
Phospholipid homeostasisIEA:Ensembl
Regulation of transforming growth factor beta activationManual Assertion Based On ExperimentIDA:UniProtKB
Response to virusIEA:Ensembl
Skin developmentIEA:Ensembl
SMAD protein signal transductionIEA:Ensembl
Surfactant homeostasisIEA:Ensembl
Transforming growth factor beta productionIEA:Ensembl
Transforming growth factor beta receptor signaling pathwayIEA:Ensembl
Wound healingIEA:Ensembl

Cellular Location

Membrane; Cell junction, focal adhesion

Involvement in disease

Amelogenesis imperfecta 1H (AI1H):
A disorder characterized by defective enamel formation, resulting in hypoplastic and hypomineralized tooth enamel that may be rough, pitted, and/or discolored.

Topology

Extracellular: 22-709
Helical: 710-730
Cytoplasmic: 731-788