Mouse Recombinant ITGB6 protein, Flag & His Tag (V2LY-0526-LY8561)

Name: Mouse Recombinant ITGB6 protein, Flag & His Tag
SKU: V2LY-0526-LY8561
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

Flag & His Tag

Protein Construction

This product is Mouse Recombinant ITGB6 protein, Flag & His Tag consist of Amino Acid: 1-988, 1-708 and predicts a molecular mass of 190.4 kDa.

Molecule Mass

190.4 kDa

Sequence

Amino Acid: 1-988, 1-708

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Sodium Citrate, NaCl, Tween80

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Integrin Subunit Beta 6

Function

Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17545607, PubMed:17158881).
It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881).
Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17545607, PubMed:17158881).
ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881).
Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447).
(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1.
(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260).

Biological Process

Bone developmentIEA:Ensembl
Bronchiole developmentIEA:Ensembl
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesion mediated by integrinManual Assertion Based On ExperimentIDA:UniProtKB
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Cell morphogenesisIEA:Ensembl
Cell-matrix adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to ionizing radiationIEA:Ensembl
Enamel mineralizationIEA:Ensembl
Hard palate developmentIEA:Ensembl
Immune responseIEA:Ensembl
Inflammatory responseIEA:Ensembl
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Langerhans cell differentiationIEA:Ensembl
Lung alveolus developmentIEA:Ensembl
Phospholipid homeostasisIEA:Ensembl
Regulation of transforming growth factor beta activationManual Assertion Based On ExperimentIDA:UniProtKB
Response to virusIEA:Ensembl
Skin developmentIEA:Ensembl
SMAD protein signal transductionIEA:Ensembl
Surfactant homeostasisIEA:Ensembl
Transforming growth factor beta productionIEA:Ensembl
Transforming growth factor beta receptor signaling pathwayIEA:Ensembl
Wound healingIEA:Ensembl

Cellular Location

Membrane; Cell junction, focal adhesion

Involvement in disease

Amelogenesis imperfecta 1H (AI1H):
A disorder characterized by defective enamel formation, resulting in hypoplastic and hypomineralized tooth enamel that may be rough, pitted, and/or discolored.

Topology

Extracellular: 22-709
Helical: 710-730
Cytoplasmic: 731-788

Sriwattanapong, K., Theerapanon, T., Boonprakong, L., Srijunbarl, A., Porntaveetus, T., & Shotelersuk, V. (2023). Novel ITGB6 variants cause hypoplastic-hypomineralized amelogenesis imperfecta and taurodontism: characterization of tooth phenotype and review of literature. BDJ open, 9(1), 15.

Lin, F., Li, X., Wang, X., Sun, H., Wang, Z., & Wang, X. (2022). Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer. Journal of Experimental & Clinical Cancer Research, 41(1), 1-25.

Krishn, S. R., Garcia, V., Naranjo, N. M., Quaglia, F., Shields, C. D., Harris, M. A., ... & Languino, L. R. (2022). Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells. Cancer Biology & Therapy, 23(1), 173-185.

You, B., Pan, S., Gu, M., Zhang, K., Xia, T., Zhang, S., ... & You, Y. (2022). Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation. Journal of Extracellular Vesicles, 11(5), e12221.

Jiang, Y., Zhou, T., Shi, Y., Feng, W., & Lyu, T. (2021). A SMYD3/ITGB6/TGFβ1 positive feedback loop promotes the invasion and adhesion of ovarian cancer spheroids. Frontiers in Oncology, 11, 690618.

Zheng, X., Zhu, Y., Wang, X., Hou, Y., & Fang, Y. (2021). Silencing of ITGB6 inhibits the progression of cervical carcinoma via regulating JAK/STAT3 signaling pathway. Annals of Translational Medicine, 9(9).

Chen, H., Chen, L., Wang, X., Ge, X., Sun, L., Wang, Z., ... & Wang, J. (2021). Transgenic overexpression of ITGB6 in intestinal epithelial cells exacerbates dextran sulfate sodium‐induced colitis in mice. Journal of Cellular and Molecular Medicine, 25(5), 2679-2690.

Meecham, A., & Marshall, J. F. (2020). The ITGB6 gene: its role in experimental and clinical biology. Gene, 763, 100023.

Weil, P., van den Bruck, R., Ziegenhals, T., Juranek, S., Goedde, D., Orth, V., ... & Postberg, J. (2020). β6 integrinosis: a new lethal autosomal recessive ITGB6 disorder leading to impaired conformational transitions of the αVβ6 integrin receptor. Gut, 69(7), 1359-1361.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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