Mouse Anti-ITGB6 Recombinant Antibody (CBYY-I1643) (CBMAB-I2813-YY)

Name: Mouse Anti-ITGB6 Recombinant Antibody (CBYY-I1643)
SKU: CBMAB-I2813-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-I1643

Application

FC, ICC, IHC-Fr, IP

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

pH 7.1

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Integrin Subunit Beta 6

Introduction

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants.

Entrez Gene ID

3694

UniProt ID

P18564

Alternative Names

Integrin Subunit Beta 6

Function

Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17545607, PubMed:17158881).
It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881).
Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17545607, PubMed:17158881).
ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881).
Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447).
(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1.
(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260).

Biological Process

Bone developmentIEA:Ensembl
Bronchiole developmentIEA:Ensembl
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesion mediated by integrinManual Assertion Based On ExperimentIDA:UniProtKB
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Cell morphogenesisIEA:Ensembl
Cell-matrix adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to ionizing radiationIEA:Ensembl
Enamel mineralizationIEA:Ensembl
Hard palate developmentIEA:Ensembl
Immune responseIEA:Ensembl
Inflammatory responseIEA:Ensembl
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Langerhans cell differentiationIEA:Ensembl
Lung alveolus developmentIEA:Ensembl
Phospholipid homeostasisIEA:Ensembl
Regulation of transforming growth factor beta activationManual Assertion Based On ExperimentIDA:UniProtKB
Response to virusIEA:Ensembl
Skin developmentIEA:Ensembl
SMAD protein signal transductionIEA:Ensembl
Surfactant homeostasisIEA:Ensembl
Transforming growth factor beta productionIEA:Ensembl
Transforming growth factor beta receptor signaling pathwayIEA:Ensembl
Wound healingIEA:Ensembl

Cellular Location

Membrane; Cell junction, focal adhesion

Involvement in disease

Amelogenesis imperfecta 1H (AI1H):
A disorder characterized by defective enamel formation, resulting in hypoplastic and hypomineralized tooth enamel that may be rough, pitted, and/or discolored.

Topology

Extracellular: 22-709
Helical: 710-730
Cytoplasmic: 731-788

Sriwattanapong, K., Theerapanon, T., Boonprakong, L., Srijunbarl, A., Porntaveetus, T., & Shotelersuk, V. (2023). Novel ITGB6 variants cause hypoplastic-hypomineralized amelogenesis imperfecta and taurodontism: characterization of tooth phenotype and review of literature. BDJ open, 9(1), 15.

Lin, F., Li, X., Wang, X., Sun, H., Wang, Z., & Wang, X. (2022). Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer. Journal of Experimental & Clinical Cancer Research, 41(1), 1-25.

Krishn, S. R., Garcia, V., Naranjo, N. M., Quaglia, F., Shields, C. D., Harris, M. A., ... & Languino, L. R. (2022). Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells. Cancer Biology & Therapy, 23(1), 173-185.

You, B., Pan, S., Gu, M., Zhang, K., Xia, T., Zhang, S., ... & You, Y. (2022). Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation. Journal of Extracellular Vesicles, 11(5), e12221.

Jiang, Y., Zhou, T., Shi, Y., Feng, W., & Lyu, T. (2021). A SMYD3/ITGB6/TGFβ1 positive feedback loop promotes the invasion and adhesion of ovarian cancer spheroids. Frontiers in Oncology, 11, 690618.

Zheng, X., Zhu, Y., Wang, X., Hou, Y., & Fang, Y. (2021). Silencing of ITGB6 inhibits the progression of cervical carcinoma via regulating JAK/STAT3 signaling pathway. Annals of Translational Medicine, 9(9).

Chen, H., Chen, L., Wang, X., Ge, X., Sun, L., Wang, Z., ... & Wang, J. (2021). Transgenic overexpression of ITGB6 in intestinal epithelial cells exacerbates dextran sulfate sodium‐induced colitis in mice. Journal of Cellular and Molecular Medicine, 25(5), 2679-2690.

Meecham, A., & Marshall, J. F. (2020). The ITGB6 gene: its role in experimental and clinical biology. Gene, 763, 100023.

Weil, P., van den Bruck, R., Ziegenhals, T., Juranek, S., Goedde, D., Orth, V., ... & Postberg, J. (2020). β6 integrinosis: a new lethal autosomal recessive ITGB6 disorder leading to impaired conformational transitions of the αVβ6 integrin receptor. Gut, 69(7), 1359-1361.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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