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Rat Anti-ITGB6 Recombinant Antibody (268622) (CBMAB-I0106-YY)

This product is Rat antibody that recognizes ITGB6. The antibody 268622 can be used for immunoassay techniques such as: ICC, IF, WB
See all ITGB6 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
268622
Antibody Isotype
IgG2a
Application
ICC, IF, WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
5% trehalose
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Integrin Subunit Beta 6
Introduction
This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
16420
UniProt ID
Q9Z0T9
Alternative Names
Integrin Subunit Beta 6
Function
Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17545607, PubMed:17158881).
It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881).
Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17545607, PubMed:17158881).
ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881).
Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447).
(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1.
(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260).
Biological Process
Bone developmentIEA:Ensembl
Bronchiole developmentIEA:Ensembl
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesion mediated by integrinManual Assertion Based On ExperimentIDA:UniProtKB
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Cell morphogenesisIEA:Ensembl
Cell-matrix adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to ionizing radiationIEA:Ensembl
Enamel mineralizationIEA:Ensembl
Hard palate developmentIEA:Ensembl
Immune responseIEA:Ensembl
Inflammatory responseIEA:Ensembl
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Langerhans cell differentiationIEA:Ensembl
Lung alveolus developmentIEA:Ensembl
Phospholipid homeostasisIEA:Ensembl
Regulation of transforming growth factor beta activationManual Assertion Based On ExperimentIDA:UniProtKB
Response to virusIEA:Ensembl
Skin developmentIEA:Ensembl
SMAD protein signal transductionIEA:Ensembl
Surfactant homeostasisIEA:Ensembl
Transforming growth factor beta productionIEA:Ensembl
Transforming growth factor beta receptor signaling pathwayIEA:Ensembl
Wound healingIEA:Ensembl
Cellular Location
Membrane; Cell junction, focal adhesion
Involvement in disease
Amelogenesis imperfecta 1H (AI1H):
A disorder characterized by defective enamel formation, resulting in hypoplastic and hypomineralized tooth enamel that may be rough, pitted, and/or discolored.
Topology
Extracellular: 22-709
Helical: 710-730
Cytoplasmic: 731-788

Sriwattanapong, K., Theerapanon, T., Boonprakong, L., Srijunbarl, A., Porntaveetus, T., & Shotelersuk, V. (2023). Novel ITGB6 variants cause hypoplastic-hypomineralized amelogenesis imperfecta and taurodontism: characterization of tooth phenotype and review of literature. BDJ open, 9(1), 15.

Lin, F., Li, X., Wang, X., Sun, H., Wang, Z., & Wang, X. (2022). Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer. Journal of Experimental & Clinical Cancer Research, 41(1), 1-25.

Krishn, S. R., Garcia, V., Naranjo, N. M., Quaglia, F., Shields, C. D., Harris, M. A., ... & Languino, L. R. (2022). Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells. Cancer Biology & Therapy, 23(1), 173-185.

You, B., Pan, S., Gu, M., Zhang, K., Xia, T., Zhang, S., ... & You, Y. (2022). Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation. Journal of Extracellular Vesicles, 11(5), e12221.

Jiang, Y., Zhou, T., Shi, Y., Feng, W., & Lyu, T. (2021). A SMYD3/ITGB6/TGFβ1 positive feedback loop promotes the invasion and adhesion of ovarian cancer spheroids. Frontiers in Oncology, 11, 690618.

Zheng, X., Zhu, Y., Wang, X., Hou, Y., & Fang, Y. (2021). Silencing of ITGB6 inhibits the progression of cervical carcinoma via regulating JAK/STAT3 signaling pathway. Annals of Translational Medicine, 9(9).

Chen, H., Chen, L., Wang, X., Ge, X., Sun, L., Wang, Z., ... & Wang, J. (2021). Transgenic overexpression of ITGB6 in intestinal epithelial cells exacerbates dextran sulfate sodium‐induced colitis in mice. Journal of Cellular and Molecular Medicine, 25(5), 2679-2690.

Meecham, A., & Marshall, J. F. (2020). The ITGB6 gene: its role in experimental and clinical biology. Gene, 763, 100023.

Weil, P., van den Bruck, R., Ziegenhals, T., Juranek, S., Goedde, D., Orth, V., ... & Postberg, J. (2020). β6 integrinosis: a new lethal autosomal recessive ITGB6 disorder leading to impaired conformational transitions of the αVβ6 integrin receptor. Gut, 69(7), 1359-1361.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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