KBTBD7

The protein encoded by this gene is a transcriptional activator, having been shown to increase the transcription of activator protein-1 and serum response element. The encoded protein can also form a complex with KBTBD6 and CUL3, which regulates the ubiquitylation and degradation of TIAM1, which is a regulator of RAC1.

Full Name

kelch repeat and BTB (POZ) domain containing 7

Function

As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205).
By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205).
Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205).

Biological Process

Negative regulation of signal transductionIEA:UniProtKB-KW
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Protein K48-linked ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of Rac protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm; Nucleus