KCNF1

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily F. This gene is intronless and expressed in all tissues tested, including the heart, skeletal muscle, brain, kidney, and pancreas.

Full Name

potassium voltage-gated channel modifier subfamily F member 1

Function

Putative voltage-gated potassium channel.

Biological Process

Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Protein homooligomerizationIEA:InterPro
Regulation of ion transmembrane transportIEA:UniProtKB-KW

Cellular Location

Membrane

Topology

Cytoplasmic: 1-183
Helical: 184-204
Helical: 224-244
Cytoplasmic: 245-249
Helical: 250-270
Helical: 290-310
Cytoplasmic: 311-324
Helical: 325-345
Pore-forming: 358-378
Helical: 386-406
Cytoplasmic: 407-494