KCTD13

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome. Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission.

Potassium Channel Tetramerization Domain Containing 13

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:19782033).
The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome (PubMed:19782033) Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity).

Cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of Rho protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of DNA replicationIEA:Ensembl
Positive regulation of synaptic transmissionISS:UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Protein homooligomerizationIEA:InterPro
Protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Stress fiber assemblyManual Assertion Based On ExperimentIMP:UniProtKB

Nucleus

The gene represented in this entry may act as a disease modifier for autism and schizophrenia associated with recurrent deletions and duplications of chromosome 16p11.2 region (PubMed:22596160, PubMed:25695269).