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Kel

This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008]
Full Name
Kell Blood Group, Metallo-Endopeptidase
Function
Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.
Biological Process
Cellular calcium ion homeostasisIEA:Ensembl
Cellular magnesium ion homeostasisIEA:Ensembl
MyelinationIEA:Ensembl
Negative regulation of potassium ion transmembrane transportIEA:Ensembl
Protein processingManual Assertion Based On ExperimentIBA:GO_Central
Regulation of axon diameterIEA:Ensembl
Regulation of cell sizeIEA:Ensembl
Skeletal muscle fiber developmentIEA:Ensembl
VasoconstrictionManual Assertion Based On ExperimentTAS:HGNC-UCL
Cellular Location
Cell membrane. Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.
Topology
Cytoplasmic: 1-47
Helical: 48-67
Extracellular: 68-732
PTM
N-glycosylated.

Anti-Kel antibodies

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Target: KEL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: BRIC107
Application*: ELISA, WB
Target: KEL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: BRIC68
Application*: ELISA, WB
Target: KEL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: BRIC18
Application*: ELISA, WB
Target: KEL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3945
Application*: C, E
Target: KEL
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXC-1459
Application*: WB
Target: KEL
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0811
Application*: F
Target: KEL
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0118-7L32
Application*: WB
Target: KEL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0435-12X3
Application*: WB
Target: KEL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BRIC203
Application*: IP
Target: KEL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B10
Application*: E
Target: KEL
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 2K15
Application*: WB
Target: KEL
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 12X3
Application*: WB
Target: KEL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Common fruit fly, Frog
Application*: IF, WB, IH
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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