Kel

This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008]

Full Name

Kell Blood Group, Metallo-Endopeptidase

Function

Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.

Biological Process

Cellular calcium ion homeostasisIEA:Ensembl
Cellular magnesium ion homeostasisIEA:Ensembl
MyelinationIEA:Ensembl
Negative regulation of potassium ion transmembrane transportIEA:Ensembl
Protein processingManual Assertion Based On ExperimentIBA:GO_Central
Regulation of axon diameterIEA:Ensembl
Regulation of cell sizeIEA:Ensembl
Skeletal muscle fiber developmentIEA:Ensembl
VasoconstrictionManual Assertion Based On ExperimentTAS:HGNC-UCL

Cellular Location

Cell membrane. Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.

Topology

Cytoplasmic: 1-47
Helical: 48-67
Extracellular: 68-732

PTM

N-glycosylated.

Anti-Kel antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-KEL Recombinant Antibody (BRIC107) (CBMAB-AP2809LY)

Datasheet

SDS

Target: KEL

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: BRIC107

Application*: ELISA, WB

Mouse Anti-KEL Recombinant Antibody (BRIC68) (CBMAB-AP2808LY)

Datasheet

SDS

Target: KEL

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: BRIC68

Application*: ELISA, WB

Mouse Anti-KEL Recombinant Antibody (BRIC18) (CBMAB-AP2807LY)

Datasheet

SDS

Target: KEL

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: BRIC18

Application*: ELISA, WB

Mouse Anti-KEL Recombinant Antibody (CBWJC-3945) (CBMAB-C5247WJ)

Datasheet

SDS

Target: KEL

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-3945

Application*: C, E

Rat Anti-KEL Recombinant Antibody (CBXC-1459) (CBMAB-C3610-CQ)

Datasheet

SDS

Target: KEL

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBXC-1459

Application*: WB

Human Anti-KEL Recombinant Antibody (CBXC-0811) (CBMAB-C1925-CQ)

Datasheet

SDS

Target: KEL

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0811

Application*: F

Rat Anti-KEL Recombinant Antibody (RM0118-7L32) (CBMAB-K0778-LY)

Datasheet

SDS

Target: KEL

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: RM0118-7L32

Application*: WB

Mouse Anti-KEL Recombinant Antibody (MM0435-12X3) (CBMAB-K0777-LY)

Datasheet

SDS

Target: KEL

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: MM0435-12X3

Application*: WB

Mouse Anti-KEL Recombinant Antibody (BRIC203) (CBMAB-K0776-LY)

Datasheet

SDS

Target: KEL

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: BRIC203

Application*: IP

Mouse Anti-KEL Recombinant Antibody (4B10) (CBMAB-K0774-LY)

Datasheet

SDS

Target: KEL

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4B10

Application*: E

Rat Anti-KEL Recombinant Antibody (2K15) (CBMAB-K0773-LY)

Datasheet

SDS

Target: KEL

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: 2K15

Application*: WB

Mouse Anti-KEL Recombinant Antibody (12X3) (CBMAB-K0770-LY)

Datasheet

SDS

Target: KEL

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: 12X3

Application*: WB

Mouse Anti-Kel Recombinant Antibody (CBMAB-0475-LY)

Datasheet

SDS

Target: KEL

Host: Mouse

Antibody Isotype: IgG1

Specificity: Common fruit fly, Frog

Application*: IF, WB, IH

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)