Kel

This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008]
Full Name
Kell Blood Group, Metallo-Endopeptidase
Function
Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.
Biological Process
Cellular calcium ion homeostasisIEA:Ensembl
Cellular magnesium ion homeostasisIEA:Ensembl
MyelinationIEA:Ensembl
Negative regulation of potassium ion transmembrane transportIEA:Ensembl
Protein processingManual Assertion Based On ExperimentIBA:GO_Central
Regulation of axon diameterIEA:Ensembl
Regulation of cell sizeIEA:Ensembl
Skeletal muscle fiber developmentIEA:Ensembl
VasoconstrictionManual Assertion Based On ExperimentTAS:HGNC-UCL
Cellular Location
Cell membrane. Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.
Topology
Cytoplasmic: 1-47
Helical: 48-67
Extracellular: 68-732
PTM
N-glycosylated.
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Anti-Kel antibodies

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Rat Anti-KEL Recombinant Antibody (2K15) (CBMAB-K0773-LY)

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Target: KEL
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 2K15
Application*: WB
Datasheet SDS

Mouse Anti-KEL Recombinant Antibody (BRIC107) (CBMAB-AP2809LY)

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Target: KEL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: BRIC107
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-KEL Recombinant Antibody (BRIC68) (CBMAB-AP2808LY)

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Target: KEL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: BRIC68
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-KEL Recombinant Antibody (BRIC18) (CBMAB-AP2807LY)

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Target: KEL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: BRIC18
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-KEL Recombinant Antibody (CBWJC-3945) (CBMAB-C5247WJ)

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Target: KEL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3945
Application*: C, E
Datasheet SDS

Rat Anti-KEL Recombinant Antibody (CBXC-1459) (CBMAB-C3610-CQ)

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Target: KEL
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXC-1459
Application*: WB
Datasheet SDS

Human Anti-KEL Recombinant Antibody (CBXC-0811) (CBMAB-C1925-CQ)

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Target: KEL
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0811
Application*: F
Datasheet SDS

Rat Anti-KEL Recombinant Antibody (RM0118-7L32) (CBMAB-K0778-LY)

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Target: KEL
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0118-7L32
Application*: WB
Datasheet SDS

Mouse Anti-KEL Recombinant Antibody (MM0435-12X3) (CBMAB-K0777-LY)

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Target: KEL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0435-12X3
Application*: WB
Datasheet SDS

Mouse Anti-KEL Recombinant Antibody (BRIC203) (CBMAB-K0776-LY)

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Target: KEL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BRIC203
Application*: IP
Datasheet SDS

Mouse Anti-KEL Recombinant Antibody (4B10) (CBMAB-K0774-LY)

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Target: KEL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B10
Application*: E
Datasheet SDS

Mouse Anti-KEL Recombinant Antibody (12X3) (CBMAB-K0770-LY)

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Target: KEL
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 12X3
Application*: WB
Datasheet SDS

Mouse Anti-Kel Recombinant Antibody (CBMAB-0475-LY)

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Target: KEL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Common fruit fly, Frog
Application*: IF, WB, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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