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Human Anti-KEL Recombinant Antibody (CBXC-0811) (CBMAB-C1925-CQ)


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Summary

Host Animal
Human
Specificity
Human
Clone
CBXC-0811
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Kell Blood Group, Metallo-Endopeptidase
Introduction
This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases.
Entrez Gene ID
3792
UniProt ID
P23276
Alternative Names
Kell Blood Group, Metallo-Endopeptidase; Truncated Kell Blood Group Glycoprotein; Kell Blood Group, Metalloendopeptidase; Kell Blood Group Glycoprotein; Kell Blood Group Antigen; Kell Glycoprotein;
Function
Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.
Biological Process
Cellular calcium ion homeostasisIEA:Ensembl
Cellular magnesium ion homeostasisIEA:Ensembl
MyelinationIEA:Ensembl
Negative regulation of potassium ion transmembrane transportIEA:Ensembl
Protein processingManual Assertion Based On ExperimentIBA:GO_Central
Regulation of axon diameterIEA:Ensembl
Regulation of cell sizeIEA:Ensembl
Skeletal muscle fiber developmentIEA:Ensembl
VasoconstrictionManual Assertion Based On ExperimentTAS:HGNC-UCL
Cellular Location
Cell membrane. Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.
Topology
Cytoplasmic: 1-47
Helical: 48-67
Extracellular: 68-732
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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