Human Anti-KEL Recombinant Antibody (CBXC-0811) (CBMAB-C1925-CQ)

Name: Human Anti-KEL Recombinant Antibody (CBXC-0811)
SKU: CBMAB-C1925-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Human

Clone

CBXC-0811

Application

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Buffer containing stabilizer

Preservative

0.05% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Kell Blood Group, Metallo-Endopeptidase

Introduction

This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases.

Entrez Gene ID

3792

UniProt ID

P23276

Alternative Names

Kell Blood Group, Metallo-Endopeptidase; Truncated Kell Blood Group Glycoprotein; Kell Blood Group, Metalloendopeptidase; Kell Blood Group Glycoprotein; Kell Blood Group Antigen; Kell Glycoprotein;

Function

Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.

Biological Process

Cellular calcium ion homeostasisIEA:Ensembl
Cellular magnesium ion homeostasisIEA:Ensembl
MyelinationIEA:Ensembl
Negative regulation of potassium ion transmembrane transportIEA:Ensembl
Protein processingManual Assertion Based On ExperimentIBA:GO_Central
Regulation of axon diameterIEA:Ensembl
Regulation of cell sizeIEA:Ensembl
Skeletal muscle fiber developmentIEA:Ensembl
VasoconstrictionManual Assertion Based On ExperimentTAS:HGNC-UCL

Cellular Location

Cell membrane. Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.

Topology

Cytoplasmic: 1-47
Helical: 48-67
Extracellular: 68-732

PTM

N-glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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