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Rat Anti-KEL Recombinant Antibody (CBXC-1459) (CBMAB-C3610-CQ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXC-1459
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to extracellular domain of mouse Kell
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized powder from PBS. Reconstitute with 200 μL PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Kell Blood Group, Metallo-Endopeptidase
Introduction
This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases.
Entrez Gene ID
23925
UniProt ID
Q9EQF2
Alternative Names
Kell Blood Group, Metallo-Endopeptidase; Truncated Kell Blood Group Glycoprotein; Kell Blood Group, Metalloendopeptidase; Kell Blood Group Glycoprotein; Kell Blood Group Antigen; Kell Glycoprotein;
Function
Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.
Biological Process
Cellular calcium ion homeostasisIEA:Ensembl
Cellular magnesium ion homeostasisIEA:Ensembl
MyelinationIEA:Ensembl
Negative regulation of potassium ion transmembrane transportIEA:Ensembl
Protein processingManual Assertion Based On ExperimentIBA:GO_Central
Regulation of axon diameterIEA:Ensembl
Regulation of cell sizeIEA:Ensembl
Skeletal muscle fiber developmentIEA:Ensembl
VasoconstrictionManual Assertion Based On ExperimentTAS:HGNC-UCL
Cellular Location
Cell membrane. Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.
Topology
Cytoplasmic: 1-47
Helical: 48-67
Extracellular: 68-732
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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