KHSRP

The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization.

KH-type splicing regulatory protein

Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity).
Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.

3'-UTR-mediated mRNA destabilizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to cytokine stimulusManual Assertion Based On ExperimentIMP:UniProtKB
miRNA metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
mRNA processingManual Assertion Based On ExperimentTAS:ProtInc
mRNA transportIEA:UniProtKB-KW
Negative regulation of low-density lipoprotein particle clearanceManual Assertion Based On ExperimentIGI:BHF-UCL
Negative regulation of nitric oxide biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of mRNA catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of mRNA stabilityManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription, DNA-templatedIEA:InterPro
RNA splicingManual Assertion Based On ExperimentTAS:UniProtKB
RNA splicing, via transesterification reactionsManual Assertion Based On ExperimentTAS:UniProtKB

Nucleus; Cytoplasm. A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.

Phosphorylation at Ser-193 leads to the unfolding of the unstable KH domain 1, creating a site for 14-3-3 YWHAZ binding, which promotes nuclear localization and impairs the RNA degradation function.