KHSRP

The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization.
Full Name
KH-type splicing regulatory protein
Function
Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity).
Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
Biological Process
3'-UTR-mediated mRNA destabilizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to cytokine stimulusManual Assertion Based On ExperimentIMP:UniProtKB
miRNA metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
mRNA processingManual Assertion Based On ExperimentTAS:ProtInc
mRNA transportIEA:UniProtKB-KW
Negative regulation of low-density lipoprotein particle clearanceManual Assertion Based On ExperimentIGI:BHF-UCL
Negative regulation of nitric oxide biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of mRNA catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of mRNA stabilityManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription, DNA-templatedIEA:InterPro
RNA splicingManual Assertion Based On ExperimentTAS:UniProtKB
RNA splicing, via transesterification reactionsManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Nucleus; Cytoplasm. A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.
PTM
Phosphorylation at Ser-193 leads to the unfolding of the unstable KH domain 1, creating a site for 14-3-3 YWHAZ binding, which promotes nuclear localization and impairs the RNA degradation function.
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Anti-KHSRP antibodies

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Mouse Anti-KHSRP Recombinant Antibody (4H7) (CBMAB-A4673-LY)

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Target: KHSRP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4H7
Application*: IH, E
Datasheet SDS

Mouse Anti-KHSRP Recombinant Antibody (2F3) (CBMAB-A4670-LY)

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Target: KHSRP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F3
Application*: WB, E
Datasheet SDS

Rabbit Anti-KHSRP Recombinant Antibody (E2E2U) (CBMAB-K0823-LY)

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Target: KHSRP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: E2E2U
Application*: WB, IP
Datasheet SDS

Rabbit Anti-KHSRP Recombinant Antibody (CBLY1-077) (CBMAB-K0817-LY)

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Target: KHSRP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLY1-077
Application*: WB, IP, P, F, IC/IF
Datasheet SDS

Mouse Anti-KHSRP Recombinant Antibody (2C7) (CBMAB-K0818-LY)

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Target: KHSRP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2C7
Application*: E, WB
Datasheet SDS

Rabbit Anti-KHSRP Recombinant Antibody (CBLY1-007) (CBMAB-K0079-LY)

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Target: KHSRP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLY1-007
Application*: IC/IF
Datasheet SDS

Human KHSRP ELISA Kit (V2LY-0626-LY4571)

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Target: KHSRP
Sensitivity: 0.013 ng/mL
Detection Range: 0.02-4.8 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Rabbit Anti-KHSRP Recombinant Antibody (EG1784) (CBMAB-EN2128-LY)

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Target: KHSRP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1784
Application*: WB: 1:500~1:1000 ELISA: 1:10000
Datasheet SDS

KHSRP Matched Antibody Pair (661) (APMAB-661LY)

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Target: KHSRP
Specificity: Human
Datasheet SDS

Mouse Anti-KHSRP Recombinant Antibody (CBXF-1823) (CBMAB-F3358-CQ)

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Target: KHSRP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1823
Application*: WB, IP, IF, P, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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