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Rabbit Anti-KHSRP Recombinant Antibody (CBLY1-007) (CBMAB-K0079-LY)

This product is antibody recognizes KHSRP. The antibody CBLY1-007 immunoassay techniques such as: ICC/IF.
See all KHSRP antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBLY1-007
Antibody Isotype
IgG
Application
ICC/IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
KH-type splicing regulatory protein
Introduction
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]
Entrez Gene ID
8570
UniProt ID
Q92945
Alternative Names
KH-Type Splicing Regulatory Protein; FUSE-Binding Protein 2; FUBP2; KSRP; P75; Far Upstream Element-Binding Protein 2; KH Type-Splicing Regulatory Protein; FUSE Binding Protein 2; FBP2;
Function
Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity).
Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
Biological Process
3'-UTR-mediated mRNA destabilizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to cytokine stimulusManual Assertion Based On ExperimentIMP:UniProtKB
miRNA metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
mRNA processingManual Assertion Based On ExperimentTAS:ProtInc
mRNA transportIEA:UniProtKB-KW
Negative regulation of low-density lipoprotein particle clearanceManual Assertion Based On ExperimentIGI:BHF-UCL
Negative regulation of nitric oxide biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of mRNA catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of mRNA stabilityManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription, DNA-templatedIEA:InterPro
RNA splicingManual Assertion Based On ExperimentTAS:UniProtKB
RNA splicing, via transesterification reactionsManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Nucleus; Cytoplasm. A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.
PTM
Phosphorylation at Ser-193 leads to the unfolding of the unstable KH domain 1, creating a site for 14-3-3 YWHAZ binding, which promotes nuclear localization and impairs the RNA degradation function.

Du, Y., Zhang, J. Y., Gong, L. P., Feng, Z. Y., Wang, D., Pan, Y. H., ... & Shao, C. K. (2022). Hypoxia-induced ebv-circLMP2A promotes angiogenesis in EBV-associated gastric carcinoma through the KHSRP/VHL/HIF1α/VEGFA pathway. Cancer letters, 526, 259-272.

Olguin, S. L., Patel, P., Buchanan, C. N., Dell’Orco, M., Gardiner, A. S., Cole, R., ... & Perrone-Bizzozero, N. I. (2022). KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization. Communications Biology, 5(1), 672.

Singh, S., Shaikh, I. A., More, S. S., Mahnashi, M. H., Almohaimeed, H. M., El-Sherbiny, M., ... & Iqubal, S. S. (2022). Blockage of KHSRP-NLRP3 by MCC950 can reverse the effect of manganese-induced neuroinflammation in N2a cells and rat brain. International Journal of Molecular Sciences, 23(21), 13224.

Xu, J., Wang, D., Ma, H., Zhai, X., Huo, Y., Ren, Y., ... & Yu, J. (2022). KHSRP combines transcriptional and posttranscriptional mechanisms to regulate monocytic differentiation. Blood Science, 4(03), 103-115.

Huang, X., Liu, X., Du, B., Liu, X., Xue, M., Yan, Q., ... & Wang, Q. (2021). LncRNA LINC01305 promotes cervical cancer progression through KHSRP and exosome-mediated transfer. Aging (Albany NY), 13(15), 19230.

Yao, X. Y., Liu, J. F., Luo, Y., Xu, X. Z., & Bu, J. (2021). LncRNA HOTTIP facilitates cell proliferation, invasion, and migration in osteosarcoma by interaction with PTBP1 to promote KHSRP level. Cell Cycle, 20(3), 283-297.

Pan, R., Cai, W., Sun, J., Yu, C., Li, P., & Zheng, M. (2020). Inhibition of KHSRP sensitizes colorectal cancer to 5‐fluoruracil through miR‐501‐5p‐mediated ERRFI1 mRNA degradation. Journal of Cellular Physiology, 235(2), 1576-1587.

Taniuchi, K., & Ogasawara, M. (2020). KHSRP-bound small nucleolar RNAs associate with promotion of cell invasiveness and metastasis of pancreatic cancer. Oncotarget, 11(2), 131.

Yan, M., Sun, L., Li, J., Yu, H., Lin, H., Yu, T., ... & Yao, M. (2019). RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer. Journal of experimental & clinical cancer research, 38, 1-17.

Gou, Q., Gao, L., Nie, X., Pu, W., Zhu, J., Wang, Y., ... & Peng, Y. (2018). Long noncoding RNA AB074169 inhibits cell proliferation via modulation of KHSRP-mediated CDKN1a expression in papillary thyroid carcinoma. Cancer research, 78(15), 4163-4174.

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For research use only. Not intended for any clinical use.

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