KIF11

This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]

Kinesin Family Member 11

Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501).
Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769).

Cell divisionIEA:UniProtKB-KW
Microtubule-based movementIEA:InterPro
Mitotic cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Mitotic centrosome separationIEA:Ensembl
Mitotic spindle assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Mitotic spindle organizationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of mitotic centrosome separationManual Assertion Based On ExperimentIMP:UniProtKB
Spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB

Cytoplasm; Cytoplasm, cytoskeleton, spindle pole

Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR):
An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.

Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase).
A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function.