Mouse Anti-KIF11 Recombinant Antibody (
11C9) (V2LY-0725-LY503)

Name: Mouse Anti-KIF11 Recombinant Antibody (11C9)
SKU: V2LY-0725-LY503
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

11C9

Application

ELISA, WB, ICC

Immunogen

Purified recombinant Human KIF11 protein fragments expressed in E.coli.

Host Species

Mouse

Specificity

Human, Dog, Rat, Pig, Cattle, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:5,000
ICC	1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Tris-Glycine, Glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Kinesin Family Member 11

Entrez Gene ID

3832

UniProt ID

P52732

Function

Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501).
Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769).

Biological Process

Cell divisionIEA:UniProtKB-KW
Microtubule-based movementIEA:InterPro
Mitotic cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Mitotic centrosome separationIEA:Ensembl
Mitotic spindle assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Mitotic spindle organizationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of mitotic centrosome separationManual Assertion Based On ExperimentIMP:UniProtKB
Spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm; Cytoplasm, cytoskeleton, spindle pole

Involvement in disease

Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR):
An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.

PTM

Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase).
A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function.

Zhang, J., Wei, Z., Qi, X., Jiang, Y., Liu, D., & Liu, K. (2023). Kinesin family member 11 promotes progression of hepatocellular carcinoma via the OCT4 pathway. Functional & Integrative Genomics, 23(3), 284.

Ling, J., Wang, Y., Ma, L., Zheng, Y., Tang, H., Meng, L., & Zhang, L. (2022). KIF11, a plus end-directed kinesin, as a key gene in benzo (a) pyrene-induced non-small cell lung cancer. Environmental Toxicology and Pharmacology, 89, 103775.

Liu, J., Tian, Y., Yi, L., Gao, Z., Lou, M., & Yuan, K. (2022). High KIF11 expression is associated with poor outcome of NSCLC. Tumori Journal, 108(1), 40-46.

Wang, Y., Smallwood, P. M., Williams, J., & Nathans, J. (2020). A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy. Human molecular genetics, 29(7), 1121-1131.

Wang, B., Yu, J., Sun, Z., Luh, F., Lin, D., Shen, Y., ... & Liu, X. (2020). Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA‐30a in breast cancer. Molecular Carcinogenesis, 59(8), 908-922.

Jin, Q., Dai, Y., Wang, Y., Zhang, S., & Liu, G. (2019). High kinesin family member 11 expression predicts poor prognosis in patients with clear cell renal cell carcinoma. Journal of clinical pathology, 72(5), 354-362.

Pei, Y. Y., Li, G. C., Ran, J., Wan, X. H., Wei, F. X., & Wang, L. (2019). Kinesin family member 11 enhances the self-renewal ability of breast cancer cells by participating in the Wnt/β-catenin pathway. Journal of Breast Cancer, 22(4), 522-532.

Swarnkar, S., Avchalumov, Y., Raveendra, B. L., Grinman, E., & Puthanveettil, S. V. (2018). Kinesin family of proteins Kif11 and Kif21B act as inhibitory constraints of excitatory synaptic transmission through distinct mechanisms. Scientific Reports, 8(1), 17419.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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