KLF1

This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.
Full Name
Kruppel like factor 15
Function
ranscription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
Biological Process
Cellular response to peptideIEA:Ensembl
Erythrocyte differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Maternal process involved in female pregnancyIEA:Ensembl
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus. Colocalizes with SUMO1 in nuclear speckles.
Involvement in disease
Anemia, congenital dyserythropoietic, 4 (CDAN4):
A blood disorder characterized by ineffective erythropoiesis and hemolysis resulting in anemia. Circulating erythroblasts and erythroblasts in the bone marrow show various morphologic abnormalities. Affected individuals with CDA4 also have increased levels of fetal hemoglobin.
PTM
Acetylated; can be acetylated on both Lys-274 and Lys-288. Acetylation on Lys-274 (by CBP) appears to be the major site affecting EKLF transactivation activity (By similarity).
Sumoylated; sumoylation, promoted by PIAS1, leads to repression of megakaryocyte differentiation. Also promotes the interaction with the CDH4 subunit of the NuRD repression complex (By similarity).
Phosphorylated primarily on serine residues in the transactivation domain. Phosphorylation on Thr-23 is critical for the transactivation activity (By similarity).
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Anti-KLF1 antibodies

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Mouse Anti-KLF1 Recombinant Antibody (7B2) (CBMAB-K1039-LY)

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Target: KLF1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Mouse
Clone: 7B2
Application*: CI, IP, WB
Datasheet SDS

Mouse Anti-KLF1 Recombinant Antibody (5G12) (CBMAB-K1038-LY)

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Target: KLF1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 5G12
Application*: IF, WB
Datasheet SDS

Mouse Anti-KLF1 Antibody (2C4) (CBMAB-0584-YC)

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Target: KLF1
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 2C4
Application*: IP, M
Datasheet SDS

Mouse Anti-KLF1 Recombinant Antibody (CBT3059) (V2LY-0625-LY18)

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Target: KLF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3059
Application*: IH, F
Datasheet SDS

Rabbit Anti-KLF1 Recombinant Antibody (EG1799) (CBMAB-EN2147-LY)

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Target: KLF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1799
Application*: WB: 1:500~1:1000 ELISA: 1:20000
Datasheet SDS

Mouse Anti-KLF1 Recombinant Antibody (4E10) (CBMAB-A4726-LY)

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Target: KLF1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 4E10
Application*: WB, E
Datasheet SDS

Mouse Anti-KLF1 Recombinant Antibody (5D7) (CBMAB-K1037-LY)

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Target: KLF1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5D7
Application*: E, WB
Datasheet SDS

Mouse Anti-KLF1 Recombinant Antibody (2A6) (CBMAB-K1036-LY)

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Target: KLF1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 2A6
Application*: WB
Datasheet SDS

Mouse Anti-KLF1 Recombinant Antibody (1E4) (CBMAB-K1035-LY)

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Target: KLF1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 1E4
Application*: E, WB
Datasheet SDS

Rabbit Anti-KLF1 Recombinant Antibody (15H43L4) (CBMAB-K1033-LY)

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Target: KLF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 15H43L4
Application*: F, IC, IF, WB
Datasheet SDS

Mouse Anti-KLF1 Recombinant Antibody (14i175) (CBMAB-K1032-LY)

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Target: KLF1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14i175
Application*: E, F, IH, WB
Datasheet SDS

Mouse Anti-KLF1 (AA 183-237) Recombinant Antibody (CBFYE-0193) (CBMAB-E0436-FY)

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Target: KLF1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBFYE-0193
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-KLF1 Recombinant Antibody (1B6A3) (CBMAB-E2104-FY)

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Target: KLF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B6A3
Application*: WB, E, P, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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