KLK3
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Full Name
Kallikrein Related Peptidase 3
Function
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
Biological Process
Cellular protein metabolic processTAS:Reactome
Negative regulation of angiogenesis1 PublicationNAS:UniProtKB
Positive regulation of antibacterial peptide productionManual Assertion Based On ExperimentIDA:UniProtKB
ProteolysisManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of systemic arterial blood pressureManual Assertion Based On ExperimentIBA:GO_Central
Zymogen activationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of angiogenesis1 PublicationNAS:UniProtKB
Positive regulation of antibacterial peptide productionManual Assertion Based On ExperimentIDA:UniProtKB
ProteolysisManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of systemic arterial blood pressureManual Assertion Based On ExperimentIBA:GO_Central
Zymogen activationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
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Anti-KLK3 antibodies
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CompareTarget: KLK3
Secondary Antibody Host Species: Goat
Secondary Antibody Species Specificity: Rabbit
Application*: IHC-P
Sample Type: FFPE tissue
Target: KLK3
Secondary Antibody Host Species: Goat
Secondary Antibody Species Specificity: Mouse
Application*: IHC-P
Sample Type: FFPE tissue
Target: KLK3
Secondary Antibody Host Species: Goat
Secondary Antibody Species Specificity: Mouse
Application*: IHC-P
Sample Type: FFPE tissue
Target: KLK3
Secondary Antibody Host Species: Goat
Secondary Antibody Species Specificity: Mouse
Application*: IHC-P
Sample Type: FFPE tissue
Target: KLK3
Secondary Antibody Host Species: Goat
Secondary Antibody Species Specificity: Mouse
Application*: IHC-P
Sample Type: FFPE tissue
Target: KLK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0028
Application*: P
Target: KLK3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-261
Tag: His Tag
Target: KLK3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-261
Tag: His Tag
Target: KLK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 7D4
Application*: E, IH
Target: KLK3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1070
Application*: WB, P, IF, F, E
Target: KLK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3017
Application*: F
Target: KLK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2721
Application*: IH, F
Target: KLK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 8
Application*: E
Target: KLK3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8A12
Application*: P
Target: KLK3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 11E9
Application*: P
Target: KLK3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 10D6
Application*: E
Target: KLK3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1E2
Application*: E, IH, WB
Target: KLK3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 214
Application*: E, IH, WB
Target: KLK3
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 823
Application*: E, F, B
Target: KLK3
Host: Human
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 661
Application*: E
Target: KLK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 906
Application*: P
Target: KLK3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2
Application*: WB, IP, IF, E, P
Target: KLK3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A4
Application*: WB, IP, F, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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