KPNA2

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Full Name
Karyopherin Subunit Alpha 2
Function
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Biological Process
DNA metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Entry of viral genome into host nucleus through nuclear pore complex via importinManual Assertion Based On ExperimentIMP:MGI
NLS-bearing protein import into nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of viral life cycleManual Assertion Based On ExperimentIMP:MGI
Postsynapse to nucleus signaling pathwayManual Assertion Based On ExperimentIDA:SynGO
Regulation of DNA recombinationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
Endoplasmic reticulum membrane
Golgi apparatus membrane
(Microbial infection) Retained in ER/Golgi membranes upon interaction with SARS-COV virus ORF6 protein.
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Anti-KPNA2 antibodies

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Mouse Anti-KPNA2 Recombinant Antibody (A780) (CBMAB-AP4078LY)

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Target: KPNA2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: A780
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-KPNA2 Recombinant Antibody (2/Karyopherin&945;) (CBMAB-K1475-LY)

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Target: KPNA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Mouse, Rat
Clone: 2/Karyopherin&945;
Application*: WB, IF, IH, IP
Datasheet SDS

Mouse Anti-KPNA2 Recombinant Antibody (CBLY1-137) (CBMAB-K1470-LY)

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Target: KPNA2
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLY1-137
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-KPNA2 Recombinant Antibody (CBLY1-135) (CBMAB-K1468-LY)

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Target: KPNA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLY1-135
Application*: WB, F
Datasheet SDS

Mouse Anti-KPNA2 Recombinant Antibody (MM0769-21G39) (CBMAB-K1476-LY)

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Target: KPNA2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: MM0769-21G39
Application*: WB
Datasheet SDS

Mouse Anti-KPNA2 Recombinant Antibody (1E8B7) (CBMAB-K1474-LY)

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Target: KPNA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 1E8B7
Application*: E, WB, P, IF/IC, F
Datasheet SDS

Rat Anti-KPNA2 Recombinant Antibody (1A6) (CBMAB-K1473-LY)

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Target: KPNA2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1A6
Application*: IC, WB
Datasheet SDS

Mouse Anti-KPNA2 Recombinant Antibody (12K121) (CBMAB-K1472-LY)

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Target: KPNA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12K121
Application*: IC
Datasheet SDS

Mouse Anti-KPNA2 Recombinant Antibody (11n120) (CBMAB-K1471-LY)

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Target: KPNA2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 11n120
Application*: WB
Datasheet SDS

Mouse Anti-KPNA2 Recombinant Antibody (CBT2792) (V2LY-0625-LY458)

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Target: KPNA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT2792
Application*: WB, IH, IC, F
Datasheet SDS

Mouse Anti-KPNA2 Recombinant Antibody (CBYY-I0693) (CBMAB-I1525-YY)

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Target: KPNA2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0693
Application*: WB, IC
Datasheet SDS

Mouse Anti-KPNA2 Recombinant Antibody (CBYY-I0692) (CBMAB-I1524-YY)

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Target: KPNA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0692
Application*: IC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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