LAMTOR3

This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase cascade.
Full Name
LATE ENDOSOMAL/LYSOSOMAL ADAPTOR, MAPK AND MTOR ACTIVATOR 3
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Biological Process
Cellular protein localizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to amino acid stimulusManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of MAPK cascadeIEA:Ensembl
Positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Protein localization to cell junctionIEA:Ensembl
Cellular Location
Late endosome membrane
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Anti-LAMTOR3 antibodies

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Rabbit Anti-LAMTOR3 Recombinant Antibody (D38G5) (CBMAB-CP1347-LY)

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Target: LAMTOR3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D38G5
Application*: WB
Datasheet SDS

Mouse Anti-LAMTOR3 Recombinant Antibody (2A4) (CBMAB-A5289-LY)

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Target: LAMTOR3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2A4
Application*: WB, E
Datasheet SDS

Mouse Anti-LAMTOR3 (AA 1-124) Recombinant Antibody (CBFYM-1207) (CBMAB-M1364-FY)

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Target: LAMTOR3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBFYM-1207
Application*: E, WB
Datasheet SDS

Mouse Anti-LAMTOR3 Recombinant Antibody (CBYJL-1181) (CBMAB-L0680-YJ)

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Target: LAMTOR3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-1181
Application*: E, WB
Datasheet SDS

Mouse Anti-LAMTOR3 Recombinant Antibody (CBYJL-1180) (CBMAB-L0679-YJ)

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Target: LAMTOR3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJL-1180
Application*: E, WB
Datasheet SDS

Rabbit Anti-LAMTOR3 Recombinant Antibody (CBYJL-1179) (CBMAB-L0678-YJ)

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Target: LAMTOR3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBYJL-1179
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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