Mouse Anti-LAMTOR3 Recombinant Antibody (CBYJL-1181) (CBMAB-L0680-YJ)

Name: Mouse Anti-LAMTOR3 Recombinant Antibody (CBYJL-1181)
SKU: CBMAB-L0680-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJL-1181

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-124

More Infomation

Target

Full Name

LATE ENDOSOMAL/LYSOSOMAL ADAPTOR, MAPK AND MTOR ACTIVATOR 3

Introduction

LAMTOR3 is a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. LAMTOR3 is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. Among its related pathways are Gene Expression and RET signaling.

Entrez Gene ID

8649

UniProt ID

Q9UHA4

Alternative Names

MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633; Ragulator3

Function

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.

Biological Process

Cellular protein localizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to amino acid stimulusManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of MAPK cascadeIEA:Ensembl
Positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Protein localization to cell junctionIEA:Ensembl

Cellular Location

Late endosome membrane

Gong, Y., Lv, Y., Xu, F., Xiu, Y., Lu, Y., Liu, Z., & Deng, L. (2022). LAMTOR3 is a prognostic biomarker in kidney renal clear cell carcinoma. Journal of Clinical Laboratory Analysis, 36(9), e24648.

Wang, Y., Chen, B., Xiao, M., Wang, X., & Peng, Y. (2022). Brucea javanica oil emulsion promotes autophagy in ovarian cancer cells through the miR-8485/LAMTOR3/mTOR/ATG13 signaling Axis. Frontiers in Pharmacology, 13, 935155.

Zhang, X., Xue, C., Cui, X., Zhou, Z., Fu, Y., Yin, X., ... & Qin, X. (2020). Circ_0075829 facilitates the progression of pancreatic carcinoma by sponging miR‐1287‐5p and activating LAMTOR3 signalling. Journal of Cellular and Molecular Medicine, 24(24), 14596-14607.

Jin, M., Cao, M., Chu, M., Piao, J. A., Guo, X., Zhao, F., & Piao, J. (2019). Gene expression and localization of LAMTOR3 in the skin cells of Liaoning cashmere goats. Animal biotechnology, 30(1), 36-42.

Cox, G. (2019). Analysis Of Danio Rerio (Zebrafish) Lamtor3 Crispr Knockouts And The Effects On Embryotic Yolk Digestion And Pigmentation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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