LANCL2
LANCL2 is necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
Full Name
LanC Like 2
Function
Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
Biological Process
Carbohydrate metabolic processIEA:InterPro
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of abscisic acid-activated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of abscisic acid-activated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Cell membrane
Localizes to the juxta-nuclear vesicles (PubMed:16979580).
Associates with the cortical actin cytoskeleton (PubMed:16979580).
Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo (PubMed:16979580).
Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin) (PubMed:16979580).
Cytoplasm
Cell membrane
Localizes to the juxta-nuclear vesicles (PubMed:16979580).
Associates with the cortical actin cytoskeleton (PubMed:16979580).
Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo (PubMed:16979580).
Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin) (PubMed:16979580).
PTM
Myristoylated. Essential for membrane association.
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Anti-LANCL2 antibodies
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Target: LANCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1414
Application*: F, P, WB
Target: LANCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1413
Application*: P, WB
Target: LANCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1184
Application*: WB, P, F
Target: LANCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C5
Application*: WB, IH
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot

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