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Mouse Anti-LANCL2 Recombinant Antibody (CBYJL-1184) (CBMAB-L0685-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lanc Like 2 (LANCL2). The antibody can be used for immunoassay techniques, such as WB, IHC-P, FC.
See all LANCL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1184
Antibody Isotype
IgG1
Application
WB, IHC-P, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LanC Like 2
Introduction
Gene Ontology (GO) annotations related to LANCL2 include GTP binding and phosphatidylinositol-4-phosphate binding. An important paralog of this gene is LANCL1.LANCL2 is necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
Entrez Gene ID
55915
UniProt ID
Q9NS86
Alternative Names
GPR69B; TASP
Function
Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
Biological Process
Carbohydrate metabolic processIEA:InterPro
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of abscisic acid-activated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Cell membrane
Localizes to the juxta-nuclear vesicles (PubMed:16979580).
Associates with the cortical actin cytoskeleton (PubMed:16979580).
Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo (PubMed:16979580).
Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin) (PubMed:16979580).
PTM
Myristoylated. Essential for membrane association.

Tubau-Juni, N., Hontecillas, R., Leber, A. J., Alva, S. S., & Bassaganya-Riera, J. (2023). Treating Autoimmune Diseases With LANCL2 Therapeutics: A Novel Immunoregulatory Mechanism for Patients With Ulcerative Colitis and Crohn’s Disease. Inflammatory Bowel Diseases, izad258.

Spinelli, S., Guida, L., Passalacqua, M., Magnone, M., Cossu, V., Sambuceti, G., ... & Zocchi, E. (2023). Abscisic Acid and Its Receptors LANCL1 and LANCL2 Control Cardiomyocyte Mitochondrial Function, Expression of Contractile, Cytoskeletal and Ion Channel Proteins and Cell Proliferation via ERRα. Antioxidants, 12(9), 1692.

Scarano, N., Di Palma, F., Origlia, N., Musumeci, F., Schenone, S., Spinelli, S., ... & Cavalli, A. (2023). New Insights into the LANCL2-ABA Binding Mode towards the Evaluation of New LANCL Agonists. Pharmaceutics, 15(12), 2754.

Maixner, D. W., Christy, D., Kong, L., Viatchenko-Karpinski, V., Horner, K. A., Hooks, S. B., & Weng, H. R. (2022). Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord. Molecular Pain, 18, 17448069221107781.

Tubau-Juni, N., Hontecillas, R., Leber, A., Maturavongsadit, P., Chauhan, J., & Bassaganya-Riera, J. (2021). First-in-class topical therapeutic omilancor ameliorates disease severity and inflammation through activation of LANCL2 pathway in psoriasis. Scientific Reports, 11(1), 19827.

Lou, Y., Xu, J., Zhang, Y., Zhang, W., Zhang, X., Gu, P., ... & Han, B. (2021). Akt kinase LANCL2 functions as a key driver in EGFR-mutant lung adenocarcinoma tumorigenesis. Cell Death & Disease, 12(2), 170.

Zhao, H. F., Zhou, X. M., Wang, J., Chen, F. F., Wu, C. P., Diao, P. Y., ... & Li, W. P. (2021). Identification of prognostic values defined by copy number variation, mRNA and protein expression of LANCL2 and EGFR in glioblastoma patients. Journal of Translational Medicine, 19(1), 1-15.

Leber, A., Hontecillas, R., Tubau-Juni, N., Zoccoli-Rodriguez, V., Goodpaster, B., & Bassaganya-Riera, J. (2020). Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle. Scientific Reports, 10(1), 10463.

Leber, A., Hontecillas, R., Zoccoli-Rodriguez, V., Ehrich, M., Davis, J., Chauhan, J., & Bassaganya-Riera, J. (2019). Nonclinical toxicology and toxicokinetic profile of an oral lanthionine synthetase C-like 2 (LANCL2) agonist, BT-11. International Journal of Toxicology, 38(2), 96-109.

Leber, A., Hontecillas, R., Zoccoli-Rodriguez, V., & Bassaganya-Riera, J. (2018). Activation of LANCL2 by BT-11 ameliorates IBD by supporting regulatory T cell stability through immunometabolic mechanisms. Inflammatory Bowel Diseases, 24(9), 1978-1991.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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