LHX6
This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq]
Full Name
LIM homeobox 6
Function
Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity).
Biological Process
Cell maturationISS:UniProtKB
Cerebral cortex GABAergic interneuron migrationISS:UniProtKB
Cerebral cortex radially oriented cell migrationISS:UniProtKB
Cerebral cortex tangential migrationISS:UniProtKB
Forebrain neuron developmentManual Assertion Based On ExperimentIBA:GO_Central
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cerebral cortex GABAergic interneuron migrationISS:UniProtKB
Cerebral cortex radially oriented cell migrationISS:UniProtKB
Cerebral cortex tangential migrationISS:UniProtKB
Forebrain neuron developmentManual Assertion Based On ExperimentIBA:GO_Central
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
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Anti-LHX6 antibodies
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Target: LHX6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D9
Application*: WB, E
Target: LHX6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: 2A2
Application*: WB, E
Target: LHX6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: 3E8
Application*: WB, E
Target: LHX6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYCL-306
Application*: E, WB
Target: LHX6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYCL-305
Application*: IF, E, WB
Target: LHX6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBYCL-304
Application*: WB
Target: LHX6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1637
Application*: WB, IP, IF, E
Target: LHX6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJL-1636
Application*: WB
Target: LHX6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJL-1635
Application*: E, WB
Target: LHX6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1634
Application*: E, WB
Target: LHX6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1633
Application*: E, WB
Target: LHX6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1632
Application*: E, IF, WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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