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Mouse Anti-LHX6 Recombinant Antibody (CBYJL-1637) (CBMAB-L1495-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lim Homeobox 6 (LHX6). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all LHX6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1637
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LIM homeobox 6
Introduction
LHX6 is a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. LHX6 has tandem LIM domains as well as a DNA-binding homeodomain. The protein functions as a transcription factor involved in embryogenesis and head development and is highly expressed in neural crest derived mesenchyme cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is LHX8.Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. It functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity).
Entrez Gene ID
26468
UniProt ID
Q9UPM6
Alternative Names
LHX6.1
Function
Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity).
Biological Process
Cell maturationISS:UniProtKB
Cerebral cortex GABAergic interneuron migrationISS:UniProtKB
Cerebral cortex radially oriented cell migrationISS:UniProtKB
Cerebral cortex tangential migrationISS:UniProtKB
Forebrain neuron developmentManual Assertion Based On ExperimentIBA:GO_Central
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus

Oh, S. G., Lee, E. Y., & Lee, H. S. (2023). Projections from LIM homeobox 6 (Lhx6)+ zona incerta neurons to the cholinergic or monoaminergic nuclei of the rat. The Anatomical Record, 306(4), 905-917.

Gao, P., Sun, N., Zhao, T., Sun, Y., Gu, J., Ma, D., ... & Qi, X. (2022). Identification of prognostic indicators, diagnostic markers, and possible therapeutic targets among LIM homeobox transcription factors in breast cancer. Cancer Innovation, 1(3), 252-269.

Abudurexiti, Y., Gu, Z., Chakma, K., Hata, T., Motoi, F., Unno, M., ... & Fukushige, S. (2020). Methylation-mediated silencing of the LIM homeobox 6 (LHX6) gene promotes cell proliferation in human pancreatic cancer. Biochemical and biophysical research communications, 526(3), 626-632.

Oh, S. G., Hwang, Y. G., & Lee, H. S. (2020). LIM homeobox 6 (Lhx6)+ neurons in the ventral zona incerta project to the core portion of the lateral supramammillary nucleus in the rat. Brain Research, 1748, 147125.

Yuan, F., Fang, K. H., Hong, Y., Xu, S. B., Xu, M., Pan, Y., & Liu, Y. (2020). LHX6 is essential for the migration of human pluripotent stem cell-derived GABAergic interneurons. Protein & Cell, 11(4), 286-291.

He, D., Guo, R., Zheng, D., Li, P., Dong, X., & Gan, L. (2019). Expression of Lhx6 in the adult and developing mouse retina. Gene Expression Patterns, 34, 119065.

Yuan, F., Chen, X., Fang, K. H., Wang, Y., Lin, M., Xu, S. B., ... & Liu, Y. (2018). Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor LIM homeobox 6. Elife, 7, e37382.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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