Mouse Anti-LHX6 Recombinant Antibody (3E8) (CBMAB-A4979-LY)

Name: Mouse Anti-LHX6 Recombinant Antibody (3E8)
SKU: CBMAB-A4979-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3E8

Application

WB, ELISA

Immunogen

LHX6 (NP_055183, 274 a.a. ~ 363 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

LIM homeobox 6

Introduction

This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq]

Entrez Gene ID

Human	26468
Mouse	16874
Rat	311901

UniProt ID

Human	Q9UPM6
Mouse	Q9R1R0
Rat	D3ZDG6

Alternative Names

LHX6.1; MGC119542; MGC119544; MGC119545

Function

Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity).

Biological Process

Cell maturationISS:UniProtKB
Cerebral cortex GABAergic interneuron migrationISS:UniProtKB
Cerebral cortex radially oriented cell migrationISS:UniProtKB
Cerebral cortex tangential migrationISS:UniProtKB
Forebrain neuron developmentManual Assertion Based On ExperimentIBA:GO_Central
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Oh, S. G., Lee, E. Y., & Lee, H. S. (2023). Projections from LIM homeobox 6 (Lhx6)+ zona incerta neurons to the cholinergic or monoaminergic nuclei of the rat. The Anatomical Record, 306(4), 905-917.

Gao, P., Sun, N., Zhao, T., Sun, Y., Gu, J., Ma, D., ... & Qi, X. (2022). Identification of prognostic indicators, diagnostic markers, and possible therapeutic targets among LIM homeobox transcription factors in breast cancer. Cancer Innovation, 1(3), 252-269.

Abudurexiti, Y., Gu, Z., Chakma, K., Hata, T., Motoi, F., Unno, M., ... & Fukushige, S. (2020). Methylation-mediated silencing of the LIM homeobox 6 (LHX6) gene promotes cell proliferation in human pancreatic cancer. Biochemical and biophysical research communications, 526(3), 626-632.

Oh, S. G., Hwang, Y. G., & Lee, H. S. (2020). LIM homeobox 6 (Lhx6)+ neurons in the ventral zona incerta project to the core portion of the lateral supramammillary nucleus in the rat. Brain Research, 1748, 147125.

Yuan, F., Fang, K. H., Hong, Y., Xu, S. B., Xu, M., Pan, Y., & Liu, Y. (2020). LHX6 is essential for the migration of human pluripotent stem cell-derived GABAergic interneurons. Protein & Cell, 11(4), 286-291.

He, D., Guo, R., Zheng, D., Li, P., Dong, X., & Gan, L. (2019). Expression of Lhx6 in the adult and developing mouse retina. Gene Expression Patterns, 34, 119065.

Yuan, F., Chen, X., Fang, K. H., Wang, Y., Lin, M., Xu, S. B., ... & Liu, Y. (2018). Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor LIM homeobox 6. Elife, 7, e37382.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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