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Mouse Anti-LHX6 Recombinant Antibody (3E8) (CBMAB-A4979-LY)

The product is antibody recognizes LHX6. The antibody 3E8 immunoassay techniques such as: WB, ELISA.
See all LHX6 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
3E8
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
LHX6 (NP_055183, 274 a.a. ~ 363 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LIM homeobox 6
Introduction
This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq]
Entrez Gene ID
Human26468
Mouse16874
Rat311901
UniProt ID
HumanQ9UPM6
MouseQ9R1R0
RatD3ZDG6
Alternative Names
LHX6.1; MGC119542; MGC119544; MGC119545
Function
Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity).
Biological Process
Cell maturationISS:UniProtKB
Cerebral cortex GABAergic interneuron migrationISS:UniProtKB
Cerebral cortex radially oriented cell migrationISS:UniProtKB
Cerebral cortex tangential migrationISS:UniProtKB
Forebrain neuron developmentManual Assertion Based On ExperimentIBA:GO_Central
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus

Oh, S. G., Lee, E. Y., & Lee, H. S. (2023). Projections from LIM homeobox 6 (Lhx6)+ zona incerta neurons to the cholinergic or monoaminergic nuclei of the rat. The Anatomical Record, 306(4), 905-917.

Gao, P., Sun, N., Zhao, T., Sun, Y., Gu, J., Ma, D., ... & Qi, X. (2022). Identification of prognostic indicators, diagnostic markers, and possible therapeutic targets among LIM homeobox transcription factors in breast cancer. Cancer Innovation, 1(3), 252-269.

Abudurexiti, Y., Gu, Z., Chakma, K., Hata, T., Motoi, F., Unno, M., ... & Fukushige, S. (2020). Methylation-mediated silencing of the LIM homeobox 6 (LHX6) gene promotes cell proliferation in human pancreatic cancer. Biochemical and biophysical research communications, 526(3), 626-632.

Oh, S. G., Hwang, Y. G., & Lee, H. S. (2020). LIM homeobox 6 (Lhx6)+ neurons in the ventral zona incerta project to the core portion of the lateral supramammillary nucleus in the rat. Brain Research, 1748, 147125.

Yuan, F., Fang, K. H., Hong, Y., Xu, S. B., Xu, M., Pan, Y., & Liu, Y. (2020). LHX6 is essential for the migration of human pluripotent stem cell-derived GABAergic interneurons. Protein & Cell, 11(4), 286-291.

He, D., Guo, R., Zheng, D., Li, P., Dong, X., & Gan, L. (2019). Expression of Lhx6 in the adult and developing mouse retina. Gene Expression Patterns, 34, 119065.

Yuan, F., Chen, X., Fang, K. H., Wang, Y., Lin, M., Xu, S. B., ... & Liu, Y. (2018). Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor LIM homeobox 6. Elife, 7, e37382.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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