LIN7A

LIN7A is involved in generating and maintaining the asymmetric distribution of channels and receptors at the cell membrane. LIN7A also is required for the localization of some specific channels and can be part of a protein complex that couples synaptic vesicle exocytosis to cell adhesion in the brain. Diseases associated with LIN7A include Pulmonary Aspergilloma and Chronic Cervicitis. Among its related pathways are Transmission across Chemical Synapses and Protein-protein interactions at synapses.

Full Name

lin-7 homolog A (C. elegans)

Function

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).
This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Biological Process

ExocytosisManual Assertion Based On ExperimentTAS:ProtInc
Inner ear developmentIEA:Ensembl
Maintenance of epithelial cell apical/basal polarityManual Assertion Based On ExperimentIBA:GO_Central
Neurotransmitter secretionManual Assertion Based On ExperimentIBA:GO_Central
Protein localization to basolateral plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Protein transportIEA:UniProtKB-KW
Protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Synaptic vesicle transportIEA:Ensembl

Cellular Location

Cell membrane
Basolateral cell membrane
Cell junction
Cell junction, synapse, postsynaptic density membrane
Cell junction, tight junction
Mainly basolateral in renal epithelial cells.