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Mouse Anti-LIN7A Recombinant Antibody (CBYJL-1749) (CBMAB-L1654-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lin-7 Homolog A Crumbs Cell Polarity Complex Component (LIN7A). The antibody can be used for immunoassay techniques, such as WB, ICC, IF.
See all LIN7A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1749
Antibody Isotype
IgG2b
Application
WB, ICC, IF

Basic Information

Immunogen
Recombinant protein encompassing a sequence within the center region of human LIN7A. The exact sequence is proprietary.
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
lin-7 homolog A (C. elegans)
Introduction
LIN7A is involved in generating and maintaining the asymmetric distribution of channels and receptors at the cell membrane. LIN7A also is required for the localization of some specific channels and can be part of a protein complex that couples synaptic vesicle exocytosis to cell adhesion in the brain. Diseases associated with LIN7A include Pulmonary Aspergilloma and Chronic Cervicitis. Among its related pathways are Transmission across Chemical Synapses and Protein-protein interactions at synapses.
Entrez Gene ID
8825
UniProt ID
O14910
Alternative Names
LIN7; MALS1; VELI1; LIN-7A; MALS-1; TIP-33
Function
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).
This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
Biological Process
ExocytosisManual Assertion Based On ExperimentTAS:ProtInc
Inner ear developmentIEA:Ensembl
Maintenance of epithelial cell apical/basal polarityManual Assertion Based On ExperimentIBA:GO_Central
Neurotransmitter secretionManual Assertion Based On ExperimentIBA:GO_Central
Protein localization to basolateral plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Protein transportIEA:UniProtKB-KW
Protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Synaptic vesicle transportIEA:Ensembl
Cellular Location
Cell membrane
Basolateral cell membrane
Cell junction
Cell junction, synapse, postsynaptic density membrane
Cell junction, tight junction
Mainly basolateral in renal epithelial cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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