lmn1

Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans.

Full Name

Lamin-1

Function

Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:11071918, PubMed:25057012).
Provides a framework for the nuclear envelope and probably also interacts with chromatin (PubMed:11071918, PubMed:25057012).
Essential to maintain the shape and integrity of the nucleus, and for DNA replication (PubMed:11071918).
Involved in spatial organization of nuclear pore complexes (PubMed:11071918).
It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans (PubMed:12064941).

Biological Process

Determination of adult lifespanManual Assertion Based On ExperimentIMP:UniProtKB
Embryo development ending in birth or egg hatchingManual Assertion Based On ExperimentIMP:UniProtKB
Germ cell developmentManual Assertion Based On ExperimentIMP:WormBase
Nuclear migration along microtubuleManual Assertion Based On ExperimentIMP:WormBase
Nuclear pore localizationManual Assertion Based On ExperimentIMP:WormBase
Nucleus organizationManual Assertion Based On ExperimentIMP:WormBase
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:WormBase
Protein localizationManual Assertion Based On ExperimentIMP:WormBase
Regulation of chromosome segregationManual Assertion Based On ExperimentIMP:WormBase
Regulation of mitotic cell cycleManual Assertion Based On ExperimentIMP:WormBase

Cellular Location

Nucleus envelope
Nucleus inner membrane
Remains in the nuclear envelope until late anaphase in early embryos. Depends on mel-28 for nuclear envelope localization after mitosis.