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Mouse Anti-lmn1 Antibody (2G1) (CBMAB-1391CQ)

This product is a mouse antibody that recognizes lmn-1. The antibody 2G1 can be used for immunoassay techniques such as: IF, WB.
See all lmn1 antibodies

Summary

Host Animal
Mouse
Specificity
C. elegans, Human
Clone
2G1
Antibody Isotype
IgM, κ
Application
IF, WB

Basic Information

Immunogen
Recombinant His6-tagged LMN-1 (aa 217-550) fusion protein
Specificity
C. elegans, Human
Antibody Isotype
IgM, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 217-550

Target

Full Name
Lamin-1
Introduction
Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans.
Entrez Gene ID
172687
UniProt ID
Q21443
Alternative Names
lmn-1; Lamin-1; lam-1
Function
Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:11071918, PubMed:25057012).
Provides a framework for the nuclear envelope and probably also interacts with chromatin (PubMed:11071918, PubMed:25057012).
Essential to maintain the shape and integrity of the nucleus, and for DNA replication (PubMed:11071918).
Involved in spatial organization of nuclear pore complexes (PubMed:11071918).
It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans (PubMed:12064941).
Biological Process
Determination of adult lifespanManual Assertion Based On ExperimentIMP:UniProtKB
Embryo development ending in birth or egg hatchingManual Assertion Based On ExperimentIMP:UniProtKB
Germ cell developmentManual Assertion Based On ExperimentIMP:WormBase
Nuclear migration along microtubuleManual Assertion Based On ExperimentIMP:WormBase
Nuclear pore localizationManual Assertion Based On ExperimentIMP:WormBase
Nucleus organizationManual Assertion Based On ExperimentIMP:WormBase
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:WormBase
Protein localizationManual Assertion Based On ExperimentIMP:WormBase
Regulation of chromosome segregationManual Assertion Based On ExperimentIMP:WormBase
Regulation of mitotic cell cycleManual Assertion Based On ExperimentIMP:WormBase
Cellular Location
Nucleus envelope
Nucleus inner membrane
Remains in the nuclear envelope until late anaphase in early embryos. Depends on mel-28 for nuclear envelope localization after mitosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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