Mouse Anti-lmn1 Antibody (2G1) (CBMAB-1391CQ)

Name: Mouse Anti-lmn1 Antibody (2G1)
SKU: CBMAB-1391CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2G1

Application

IF, WB

Immunogen

Recombinant His6-tagged LMN-1 (aa 217-550) fusion protein

Specificity

C. elegans, Human

Antibody Isotype

IgM, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 217-550

More Infomation

Target

Full Name

Lamin-1

Introduction

Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans.

Entrez Gene ID

172687

UniProt ID

Q21443

Alternative Names

lmn-1; Lamin-1; lam-1

Function

Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:11071918, PubMed:25057012).
Provides a framework for the nuclear envelope and probably also interacts with chromatin (PubMed:11071918, PubMed:25057012).
Essential to maintain the shape and integrity of the nucleus, and for DNA replication (PubMed:11071918).
Involved in spatial organization of nuclear pore complexes (PubMed:11071918).
It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans (PubMed:12064941).

Biological Process

Determination of adult lifespanManual Assertion Based On ExperimentIMP:UniProtKB
Embryo development ending in birth or egg hatchingManual Assertion Based On ExperimentIMP:UniProtKB
Germ cell developmentManual Assertion Based On ExperimentIMP:WormBase
Nuclear migration along microtubuleManual Assertion Based On ExperimentIMP:WormBase
Nuclear pore localizationManual Assertion Based On ExperimentIMP:WormBase
Nucleus organizationManual Assertion Based On ExperimentIMP:WormBase
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:WormBase
Protein localizationManual Assertion Based On ExperimentIMP:WormBase
Regulation of chromosome segregationManual Assertion Based On ExperimentIMP:WormBase
Regulation of mitotic cell cycleManual Assertion Based On ExperimentIMP:WormBase

Cellular Location

Nucleus envelope
Nucleus inner membrane
Remains in the nuclear envelope until late anaphase in early embryos. Depends on mel-28 for nuclear envelope localization after mitosis.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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