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LSM8

LSM8 is a member of the like-Sm family of proteins. LSM8 consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus.

Full Name

LSM8 homolog, U6 small nuclear RNA associated

Function

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166).
The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).

Biological Process

mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
RNA metabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

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Anti-LSM8 antibodies

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Mouse Anti-LSM8 Recombinant Antibody (CBYJL-2089) (CBMAB-L2231-YJ)

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Target: LSM8

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBYJL-2089

Application*: WB, IP, IF, P, E

Mouse Anti-LSM8 Recombinant Antibody (CBYJL-2088) (CBMAB-L2230-YJ)

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Target: LSM8

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-2088

Application*: IC, WB

Mouse Anti-LSM8 Recombinant Antibody (2527C6a) (CBMAB-L2229-YJ)

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Target: LSM8

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2527C6a

Application*: DB, IC, IF, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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