LSM8

LSM8 is a member of the like-Sm family of proteins. LSM8 consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus.

Full Name

LSM8 homolog, U6 small nuclear RNA associated

Function

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166).
The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).

Biological Process

mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
RNA metabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Anti-LSM8 antibodies

Mouse Anti-LSM8 Recombinant Antibody (2527C6a) (CBMAB-L2229-YJ)

Datasheet

SDS

Target: LSM8

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2527C6a

Application*: DB, IC, IF, WB

Mouse Anti-LSM8 Recombinant Antibody (CBYJL-2088) (CBMAB-L2230-YJ)

Datasheet

SDS

Target: LSM8

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-2088

Application*: IC, WB

Mouse Anti-LSM8 Recombinant Antibody (CBYJL-2089) (CBMAB-L2231-YJ)

Datasheet

SDS

Target: LSM8

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBYJL-2089

Application*: WB, IP, IF, P, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)