Mouse Anti-LSM8 Recombinant Antibody (2527C6a) (CBMAB-L2229-YJ)

Name: Mouse Anti-LSM8 Recombinant Antibody (2527C6a)
SKU: CBMAB-L2229-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2527C6a

Application

Dot, ICC, IF, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2, 1% BSA

Preservative

0.05% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

LSM8 homolog, U6 small nuclear RNA associated

Introduction

LSM8 is a member of the like-Sm family of proteins. LSM8 consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and function in the general maturation of RNA in the nucleus.

Entrez Gene ID

51691

UniProt ID

O95777

Alternative Names

NAA38; LSM8 homolog, U6 small nuclear RNA associated; LSM8 U6 small nuclear RNA associated; MAK31-like protein; N-alpha-acetyltransferase 38, NatC auxiliary subunit; U6 snRNA-associated Sm-like protein LSm8

Function

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166).
The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).

Biological Process

mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
RNA metabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Zhu, V. W., Zhang, S. S., Zhang, J., Swensen, J., Xiu, J., & Ou, S. H. I. (2021). Acquired tertiary MET resistance (MET D1228N and a Novel LSM8-MET Fusion) to Selpercatinib and Capmatinib in a patient with KIF5B-RET–positive NSCLC with Secondary MET amplification as initial resistance to selpercatinib. Journal of Thoracic Oncology, 16(7), e51-e54.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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