MAFG

Globin gene expression is regulated through nuclear factor erythroid-2 elements located in enhancer-like locus control regions positioned many kb upstream of alpha-and beta-gene clusters. NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein and the tissue-restricted protein p45 NFE2. Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper proteins.

Full Name

MAFG

Function

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691).
However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691).
Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691).
Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691).
Activates globin gene expression when associated with NFE2L2 (PubMed:11154691).
May be involved in signal transduction of extracellular H(+) (By similarity).

Biological Process

Adult behaviorIEA:Ensembl
In utero embryonic developmentIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Regulation of cell population proliferationIEA:Ensembl
Regulation of cellular pHIEA:Ensembl
Regulation of epidermal cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

PTM

Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2.
Sumoylation at Lys-14 is required for active transcriptional repression.