MAGI1

The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

membrane associated guanylate kinase, WW and PDZ domain containing 1

May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).

Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of cell-cell adhesionManual Assertion Based On ExperimentIDA:ARUK-UCL
Protein-containing complex assembly1 PublicationNAS:ProtInc
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cell junction, tight junction
Cell membrane
Localizes to epithelial cells tight junctions.