Mouse Anti-MAGI1 Recombinant Antibody (7B4) (CBMAB-A5174-LY)

Name: Mouse Anti-MAGI1 Recombinant Antibody (7B4)
SKU: CBMAB-A5174-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

7B4

Application

WB, ELISA

Immunogen

MAGI1 (NP_004733, 761 a.a. ~ 859 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

membrane associated guanylate kinase, WW and PDZ domain containing 1

Introduction

The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Entrez Gene ID

Human	9223
Rat	500261

UniProt ID

Human	Q96QZ7
Rat	Q4L1J4

Alternative Names

AIP3; BAIAP1; BAP1; MAGI-1; TNRC19; WWP3

Function

May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).

Biological Process

Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of cell-cell adhesionManual Assertion Based On ExperimentIDA:ARUK-UCL
Protein-containing complex assembly1 PublicationNAS:ProtInc
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell junction, tight junction
Cell membrane
Localizes to epithelial cells tight junctions.

Excoffon, K. J., Avila, C. L., Alghamri, M. S., & Kolawole, A. O. (2022). The magic of MAGI‐1: A scaffolding protein with multi signalosomes and functional plasticity. Biology of the Cell, 114(7), 185-198.

Wörthmüller, J., & Rüegg, C. (2021). MAGI1, a scaffold protein with tumor suppressive and vascular functions. Cells, 10(6), 1494.

Cao, C., Li, J., Li, G., Hu, G., Deng, Z., Huang, B., ... & Cao, S. (2021). Long non-coding RNA TMEM220-AS1 suppressed hepatocellular carcinoma by regulating the miR-484/MAGI1 axis as a competing endogenous RNA. Frontiers in Cell and Developmental Biology, 9, 681529.

Ma, X., Zhang, X., Luo, J., Liang, B., Peng, J., Chen, C., ... & Xiao, Y. (2020). MiR-486-5p-directed MAGI1/Rap1/RASSF5 signaling pathway contributes to hydroquinone-induced inhibition of erythroid differentiation in K562 cells. Toxicology in Vitro, 66, 104830.

Alday-Parejo, B., Richard, F., Wörthmüller, J., Rau, T., Galván, J. A., Desmedt, C., ... & Rüegg, C. (2020). MAGI1, a new potential tumor suppressor gene in estrogen receptor positive breast cancer. Cancers, 12(1), 223.

Zhao, Y., Chen, H., Yang, Y., Wu, Q., & Wang, D. (2020). Graphene oxide disrupts the protein-protein interaction between Neuroligin/NLG-1 and DLG-1 or MAGI-1 in nematode Caenorhabditis elegans. Science of the Total Environment, 700, 134492.

Ghimire, K., Zaric, J., Alday-Parejo, B., Seebach, J., Bousquenaud, M., Stalin, J., ... & Rüegg, C. (2019). MAGI1 mediates eNOS activation and NO production in endothelial cells in response to fluid shear stress. Cells, 8(5), 388.

Abe, J. I., Ko, K. A., Kotla, S., Wang, Y., Paez-Mayorga, J., Shin, I. J., ... & Le, N. T. (2019). MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. JCI insight, 4(7).

Wang, W., Yang, Y., Chen, X., Shao, S., Hu, S., & Zhang, T. (2019). MAGI1 mediates tumor metastasis through c-Myb/miR-520h/MAGI1 signaling pathway in renal cell carcinoma. Apoptosis, 24, 837-848.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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