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Mouse Anti-MAGI1 Recombinant Antibody (7B4) (CBMAB-A5174-LY)

The product is antibody recognizes MAGI1. The antibody 7B4 immunoassay techniques such as: WB, ELISA.
See all MAGI1 antibodies
Published Data
Fig.1 MAGI-1 PDZ3 decreases viral infection, while PDZ1 inhibits MAGI-1-mediated CAREx8 suppression to allow adenovirus infection.
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Fig.2 Binding of murine MAGI-1c protein to murine Cdh23.
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Fig.3 MAGI-1 immunolocalization in P3 mouse cochlear hair cells. Shown are single confocal sections.
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Fig.4 MAGI-1 immunolocalization in the apical turn of 12-week-oldmousecochlear inner haircells.
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Fig.5 MAGI-1 immunolocalization intheapicalturnof12-week-oldmousecochlearouter haircells.
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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
7B4
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
MAGI1 (NP_004733, 761 a.a. ~ 859 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
membrane associated guanylate kinase, WW and PDZ domain containing 1
Introduction
The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
Entrez Gene ID
Human9223
Rat500261
UniProt ID
HumanQ96QZ7
RatQ4L1J4
Alternative Names
AIP3; BAIAP1; BAP1; MAGI-1; TNRC19; WWP3
Function
May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).
Biological Process
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of cell-cell adhesionManual Assertion Based On ExperimentIDA:ARUK-UCL
Protein-containing complex assembly1 PublicationNAS:ProtInc
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell junction, tight junction
Cell membrane
Localizes to epithelial cells tight junctions.

Excoffon, K. J., Avila, C. L., Alghamri, M. S., & Kolawole, A. O. (2022). The magic of MAGI‐1: A scaffolding protein with multi signalosomes and functional plasticity. Biology of the Cell, 114(7), 185-198.

Wörthmüller, J., & Rüegg, C. (2021). MAGI1, a scaffold protein with tumor suppressive and vascular functions. Cells, 10(6), 1494.

Cao, C., Li, J., Li, G., Hu, G., Deng, Z., Huang, B., ... & Cao, S. (2021). Long non-coding RNA TMEM220-AS1 suppressed hepatocellular carcinoma by regulating the miR-484/MAGI1 axis as a competing endogenous RNA. Frontiers in Cell and Developmental Biology, 9, 681529.

Ma, X., Zhang, X., Luo, J., Liang, B., Peng, J., Chen, C., ... & Xiao, Y. (2020). MiR-486-5p-directed MAGI1/Rap1/RASSF5 signaling pathway contributes to hydroquinone-induced inhibition of erythroid differentiation in K562 cells. Toxicology in Vitro, 66, 104830.

Alday-Parejo, B., Richard, F., Wörthmüller, J., Rau, T., Galván, J. A., Desmedt, C., ... & Rüegg, C. (2020). MAGI1, a new potential tumor suppressor gene in estrogen receptor positive breast cancer. Cancers, 12(1), 223.

Zhao, Y., Chen, H., Yang, Y., Wu, Q., & Wang, D. (2020). Graphene oxide disrupts the protein-protein interaction between Neuroligin/NLG-1 and DLG-1 or MAGI-1 in nematode Caenorhabditis elegans. Science of the Total Environment, 700, 134492.

Ghimire, K., Zaric, J., Alday-Parejo, B., Seebach, J., Bousquenaud, M., Stalin, J., ... & Rüegg, C. (2019). MAGI1 mediates eNOS activation and NO production in endothelial cells in response to fluid shear stress. Cells, 8(5), 388.

Abe, J. I., Ko, K. A., Kotla, S., Wang, Y., Paez-Mayorga, J., Shin, I. J., ... & Le, N. T. (2019). MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. JCI insight, 4(7).

Wang, W., Yang, Y., Chen, X., Shao, S., Hu, S., & Zhang, T. (2019). MAGI1 mediates tumor metastasis through c-Myb/miR-520h/MAGI1 signaling pathway in renal cell carcinoma. Apoptosis, 24, 837-848.

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For research use only. Not intended for any clinical use.

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