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Mouse Anti-MAGI1 Recombinant Antibody (CBFYM-0539) (CBMAB-M0668-FY)

This product is mouse antibody that recognizes MAGI1. The antibody CBFYM-0539 can be used for immunoassay techniques such as: ELISA, WB.
See all MAGI1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0539
Antibody Isotype
IgG1, k
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
membrane associated guanylate kinase, WW and PDZ domain containing 1
Introduction
The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified.
Entrez Gene ID
9223
UniProt ID
Q96QZ7
Alternative Names
Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 1; BAI1-Associated Protein 1; Membrane-Associated Guanylate Kinase Inverted 1; Trinucleotide Repeat-Containing Gene 19 Protein; Atrophin-1-Interacting Protein 3; WW Domain-Containing Protein 3; BAIAP1; MAGI-1; TNRC19
Function
May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).
Biological Process
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of cell-cell adhesionManual Assertion Based On ExperimentIDA:ARUK-UCL
Protein-containing complex assembly1 PublicationNAS:ProtInc
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell junction, tight junction
Cell membrane
Localizes to epithelial cells tight junctions.

Excoffon, K. J., Avila, C. L., Alghamri, M. S., & Kolawole, A. O. (2022). The magic of MAGI‐1: A scaffolding protein with multi signalosomes and functional plasticity. Biology of the Cell, 114(7), 185-198.

Wörthmüller, J., & Rüegg, C. (2021). MAGI1, a scaffold protein with tumor suppressive and vascular functions. Cells, 10(6), 1494.

Cao, C., Li, J., Li, G., Hu, G., Deng, Z., Huang, B., ... & Cao, S. (2021). Long non-coding RNA TMEM220-AS1 suppressed hepatocellular carcinoma by regulating the miR-484/MAGI1 axis as a competing endogenous RNA. Frontiers in Cell and Developmental Biology, 9, 681529.

Ma, X., Zhang, X., Luo, J., Liang, B., Peng, J., Chen, C., ... & Xiao, Y. (2020). MiR-486-5p-directed MAGI1/Rap1/RASSF5 signaling pathway contributes to hydroquinone-induced inhibition of erythroid differentiation in K562 cells. Toxicology in Vitro, 66, 104830.

Alday-Parejo, B., Richard, F., Wörthmüller, J., Rau, T., Galván, J. A., Desmedt, C., ... & Rüegg, C. (2020). MAGI1, a new potential tumor suppressor gene in estrogen receptor positive breast cancer. Cancers, 12(1), 223.

Zhao, Y., Chen, H., Yang, Y., Wu, Q., & Wang, D. (2020). Graphene oxide disrupts the protein-protein interaction between Neuroligin/NLG-1 and DLG-1 or MAGI-1 in nematode Caenorhabditis elegans. Science of the Total Environment, 700, 134492.

Ghimire, K., Zaric, J., Alday-Parejo, B., Seebach, J., Bousquenaud, M., Stalin, J., ... & Rüegg, C. (2019). MAGI1 mediates eNOS activation and NO production in endothelial cells in response to fluid shear stress. Cells, 8(5), 388.

Abe, J. I., Ko, K. A., Kotla, S., Wang, Y., Paez-Mayorga, J., Shin, I. J., ... & Le, N. T. (2019). MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. JCI insight, 4(7).

Wang, W., Yang, Y., Chen, X., Shao, S., Hu, S., & Zhang, T. (2019). MAGI1 mediates tumor metastasis through c-Myb/miR-520h/MAGI1 signaling pathway in renal cell carcinoma. Apoptosis, 24, 837-848.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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