MAP1S

MAP1S (Microtubule Associated Protein 1S) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding and actin filament binding. An important paralog of this gene is MAP1B.

Full Name

microtubule-associated protein 1S

Function

Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).

Biological Process

Apoptotic processIEA:UniProtKB-KW
AutophagyManual Assertion Based On ExperimentTAS:BHF-UCL
AxonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Brain developmentBy SimilarityISS:HGNC-UCL
Dendrite developmentManual Assertion Based On ExperimentIBA:GO_Central
Microtubule bundle formationManual Assertion Based On ExperimentIMP:HGNC-UCL
Microtubule cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Mitochondrion transport along microtubuleManual Assertion Based On ExperimentTAS:HGNC-UCL
Nervous system developmentBy SimilarityISS:HGNC-UCL
Neuron projection morphogenesisManual Assertion Based On ExperimentIEP:HGNC-UCL
Regulation of chromatin disassemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of microtubule depolymerizationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Cytoplasm, cytosol
Cytoplasm, cytoskeleton
Cytoplasm, cytoskeleton, spindle
Detected in filopodia-like protrusions and synapses (By similarity).
Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1 isoform A. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules.