Mouse Anti-MAP1S Recombinant Antibody (4H2) (CBMAB-A5188-LY)

Name: Mouse Anti-MAP1S Recombinant Antibody (4H2)
SKU: CBMAB-A5188-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4H2

Application

WB, ELISA

Immunogen

MAP1S (NP_060644.4, 929 a.a. ~ 1026 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

microtubule-associated protein 1S

Entrez Gene ID

55201

UniProt ID

Q66K74

Alternative Names

BPY2IP1; C19orf5; FLJ10669; MAP8; MGC133087; VCY2IP-1; VCY2IP1

Function

Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).

Biological Process

Apoptotic processIEA:UniProtKB-KW
AutophagyManual Assertion Based On ExperimentTAS:BHF-UCL
AxonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Brain developmentBy SimilarityISS:HGNC-UCL
Dendrite developmentManual Assertion Based On ExperimentIBA:GO_Central
Microtubule bundle formationManual Assertion Based On ExperimentIMP:HGNC-UCL
Microtubule cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Mitochondrion transport along microtubuleManual Assertion Based On ExperimentTAS:HGNC-UCL
Nervous system developmentBy SimilarityISS:HGNC-UCL
Neuron projection morphogenesisManual Assertion Based On ExperimentIEP:HGNC-UCL
Regulation of chromatin disassemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of microtubule depolymerizationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Cytoplasm, cytosol
Cytoplasm, cytoskeleton
Cytoplasm, cytoskeleton, spindle
Detected in filopodia-like protrusions and synapses (By similarity).
Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1 isoform A. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules.

Shi, B., Wang, W., Ye, M., Liang, M., Yu, Z., Zhang, Y., ... & Liu, L. (2023). Spermidine suppresses the activation of hepatic stellate cells to cure liver fibrosis through autophagy activator MAP1S. Liver International, 43(6), 1307-1319.

Wang, J., Zhang, X., Yang, F., Yang, Y., Wang, T., Liu, W., ... & Zhao, W. (2021). RASSF1A enhances chemosensitivity of NSCLC Cells through activating autophagy by regulating MAP1S to inactivate Keap1-Nrf2 pathway. Drug Design, Development and Therapy, 21-35.

Wang, Y., Zhang, S., Dang, S., Fang, X., & Liu, M. (2019). Overexpression of microRNA-216a inhibits autophagy by targeting regulated MAP1S in colorectal cancer. OncoTargets and therapy, 4621-4629.

Liu, P., de la Vega, M. R., Dodson, M., Yue, F., Shi, B., Fang, D., ... & Zhang, D. D. (2019). Spermidine confers liver protection by enhancing NRF2 signaling through a MAP1S‐mediated noncanonical mechanism. Hepatology, 70(1), 372-388.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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