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Mouse Anti-MAP1S Recombinant Antibody (4H2) (CBMAB-A5188-LY)

The product is antibody recognizes MAP1S. The antibody 4H2 immunoassay techniques such as: WB, ELISA.
See all MAP1S antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4H2
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MAP1S (NP_060644.4, 929 a.a. ~ 1026 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
microtubule-associated protein 1S
Entrez Gene ID
55201
UniProt ID
Q66K74
Alternative Names
BPY2IP1; C19orf5; FLJ10669; MAP8; MGC133087; VCY2IP-1; VCY2IP1
Function
Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).
Biological Process
Apoptotic processIEA:UniProtKB-KW
AutophagyManual Assertion Based On ExperimentTAS:BHF-UCL
AxonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Brain developmentBy SimilarityISS:HGNC-UCL
Dendrite developmentManual Assertion Based On ExperimentIBA:GO_Central
Microtubule bundle formationManual Assertion Based On ExperimentIMP:HGNC-UCL
Microtubule cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Mitochondrion transport along microtubuleManual Assertion Based On ExperimentTAS:HGNC-UCL
Nervous system developmentBy SimilarityISS:HGNC-UCL
Neuron projection morphogenesisManual Assertion Based On ExperimentIEP:HGNC-UCL
Regulation of chromatin disassemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of microtubule depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Cytoplasm, cytosol
Cytoplasm, cytoskeleton
Cytoplasm, cytoskeleton, spindle
Detected in filopodia-like protrusions and synapses (By similarity).
Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1 isoform A. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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