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MAP3K13

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]

Full Name

Mitogen-Activated Protein Kinase Kinase Kinase 13

Function

Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.

Biological Process

JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-serine phosphorylationISS:BHF-UCL
Positive regulation of axon extensionISS:ARUK-UCL
Positive regulation of branching morphogenesis of a nerveISS:ARUK-UCL
Positive regulation of JUN kinase activityISS:ARUK-UCL
Positive regulation of neuron maturationISS:ARUK-UCL
Positive regulation of neuron projection arborizationISS:ARUK-UCL
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Membrane

PTM

Autophosphorylated on serine and threonine residues.

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Anti-MAP3K13 antibodies

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Mouse Anti-MAP3K13 Recombinant Antibody (4H7) (CBMAB-A5206-LY)

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Target: MAP3K13

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4H7

Application*: WB, E

Human Recombinant MAP3K13, Active protein, GST Tag (V2LY-0526-LY5431)

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Target: MAP3K13

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 1-427

Tag: GST Tag

MAP3K13 Matched Antibody Pair (713) (APMAB-713LY)

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Target: MAP3K13

Specificity: Human

Mouse Anti-MAP3K13 (AA 711-810) Recombinant Antibody (CBFYM-1513) (CBMAB-M1676-FY)

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Target: MAP3K13

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-1513

Application*: E, IF, WB

Mouse Anti-MAP3K13 (N-terminus) Recombinant Antibody (CBFYM-1512) (CBMAB-M1675-FY)

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Target: MAP3K13

Host: Mouse

Antibody Isotype: IgM

Specificity: Human

Clone: CBFYM-1512

Application*: IF, WB

Mouse Anti-MAP3K13 Recombinant Antibody (CBFYM-0557) (CBMAB-M0686-FY)

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Target: MAP3K13

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-0557

Application*: E, WB

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Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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