MAP3K13

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]

Full Name

Mitogen-Activated Protein Kinase Kinase Kinase 13

Function

Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.

Biological Process

JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-serine phosphorylationISS:BHF-UCL
Positive regulation of axon extensionISS:ARUK-UCL
Positive regulation of branching morphogenesis of a nerveISS:ARUK-UCL
Positive regulation of JUN kinase activityISS:ARUK-UCL
Positive regulation of neuron maturationISS:ARUK-UCL
Positive regulation of neuron projection arborizationISS:ARUK-UCL
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Membrane

PTM

Autophosphorylated on serine and threonine residues.