MAP3K13

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]
Full Name
Mitogen-Activated Protein Kinase Kinase Kinase 13
Function
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.
Biological Process
JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-serine phosphorylationISS:BHF-UCL
Positive regulation of axon extensionISS:ARUK-UCL
Positive regulation of branching morphogenesis of a nerveISS:ARUK-UCL
Positive regulation of JUN kinase activityISS:ARUK-UCL
Positive regulation of neuron maturationISS:ARUK-UCL
Positive regulation of neuron projection arborizationISS:ARUK-UCL
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Membrane
PTM
Autophosphorylated on serine and threonine residues.
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Anti-MAP3K13 antibodies

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Mouse Anti-MAP3K13 Recombinant Antibody (4H7) (CBMAB-A5206-LY)

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Target: MAP3K13
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4H7
Application*: WB, E
Datasheet SDS

MAP3K13 Matched Antibody Pair (713) (APMAB-713LY)

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Target: MAP3K13
Specificity: Human
Datasheet SDS

Mouse Anti-MAP3K13 (AA 711-810) Recombinant Antibody (CBFYM-1513) (CBMAB-M1676-FY)

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Target: MAP3K13
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1513
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-MAP3K13 (N-terminus) Recombinant Antibody (CBFYM-1512) (CBMAB-M1675-FY)

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Target: MAP3K13
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBFYM-1512
Application*: IF, WB
Datasheet SDS

Mouse Anti-MAP3K13 Recombinant Antibody (CBFYM-0557) (CBMAB-M0686-FY)

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Target: MAP3K13
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-0557
Application*: E, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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