Mouse Anti-MAP3K13 Recombinant Antibody (4H7) (CBMAB-A5206-LY)

Name: Mouse Anti-MAP3K13 Recombinant Antibody (4H7)
SKU: CBMAB-A5206-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4H7

Application

WB, ELISA

Immunogen

MAP3K13 (NP_004712.1, 711 a.a. ~ 810 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Mitogen-Activated Protein Kinase Kinase Kinase 13

Introduction

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq]

Entrez Gene ID

9175

UniProt ID

O43283

Alternative Names

LZK; MGC133196

Function

Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.

Biological Process

JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-serine phosphorylationISS:BHF-UCL
Positive regulation of axon extensionISS:ARUK-UCL
Positive regulation of branching morphogenesis of a nerveISS:ARUK-UCL
Positive regulation of JUN kinase activityISS:ARUK-UCL
Positive regulation of neuron maturationISS:ARUK-UCL
Positive regulation of neuron projection arborizationISS:ARUK-UCL
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Membrane

PTM

Autophosphorylated on serine and threonine residues.

Sasaki, M., Hirono, S., Gao, Y., Suda, I., Matsutani, T., Ota, M., ... & Iwadate, Y. (2022). Clinicopathological and genomic features of Pediatric Intracranial Myxoid Mesenchymal Tumor with both of EWSR1-CREM Gene Fusion and MAP3K13 Mutation: a case report and comparison with adult cases in the literature. NMC Case Report Journal, 9, 101-109.

Fu, D., Ren, Y., Wang, C., Yu, L., & Yu, R. (2021). LINC01287 facilitates proliferation, migration, invasion and EMT of colon cancer cells via miR-4500/MAP3K13 pathway. BMC cancer, 21(1), 1-14.

Geng, X., Zhao, J., Huang, J., Li, S., Chu, W., Wang, W. S., ... & Du, Y. (2021). lnc-MAP3K13-7: 1 inhibits ovarian GC proliferation in PCOS via DNMT1 downregulation-mediated CDKN1A promoter hypomethylation. Molecular Therapy, 29(3), 1279-1293.

Zhang, Q., Li, X., Cui, K., Liu, C., Wu, M., Prochownik, E. V., & Li, Y. (2020). The MAP3K13-TRIM25-FBXW7α axis affects c-Myc protein stability and tumor development. Cell Death & Differentiation, 27(2), 420-433.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

MAP3K13 Matched Antibody Pair (713) (CAT#: APMAB-713LY)

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Mouse Anti-MAP3K13 Recombinant Antibody (CBFYM-0557) (CAT#: CBMAB-M0686-FY)

MAP3K13 Matched Antibody Pair (713) (CAT#: APMAB-713LY)

Mouse Anti-MAP3K13 (AA 711-810) Recombinant Antibody (CBFYM-1513) (CAT#: CBMAB-M1676-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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