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Mouse Anti-MAP3K13 Recombinant Antibody (4H7) (CBMAB-A5206-LY)

The product is antibody recognizes MAP3K13. The antibody 4H7 immunoassay techniques such as: WB, ELISA.
See all MAP3K13 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4H7
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MAP3K13 (NP_004712.1, 711 a.a. ~ 810 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Mitogen-Activated Protein Kinase Kinase Kinase 13
Introduction
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq]
Entrez Gene ID
9175
UniProt ID
O43283
Alternative Names
LZK; MGC133196
Function
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.
Biological Process
JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-serine phosphorylationISS:BHF-UCL
Positive regulation of axon extensionISS:ARUK-UCL
Positive regulation of branching morphogenesis of a nerveISS:ARUK-UCL
Positive regulation of JUN kinase activityISS:ARUK-UCL
Positive regulation of neuron maturationISS:ARUK-UCL
Positive regulation of neuron projection arborizationISS:ARUK-UCL
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Membrane
PTM
Autophosphorylated on serine and threonine residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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