MAP6

This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Full Name

Microtubule Associated Protein 6

Function

Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity).
Specifically has microtubule cold stabilizing activity (By similarity).
Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581).
Regulates KIF5A-mediated axonal cargo transport (By similarity).
Regulates axonal growth during neuron polarization (By similarity).

Biological Process

Cytoskeleton-dependent intracellular transportManual Assertion Based On ExperimentIBA:GO_Central
Dendrite morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Lysosome localizationManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule cytoskeleton organizationIEA:InterPro
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of microtubule cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm, cytoskeleton
Golgi apparatus
Cell projection, axon
Cell projection, dendrite
Cytoplasmic vesicle, secretory vesicle membrane
Localizes predominantly in the proximal part of the axon (By similarity).
Preferentially is concentrated on a portion of the microtubule polymer in which tubulin is modified by detyrosination and acetylation and is also resistant to depolymerization induced by both nocodazole and cold (By similarity).
In unpolarized neurons, localizes to the Golgi and to secretory vesicles accumulating transiently at the tips of a subset of neurites (By similarity).
Following neuronal polarization and during axon outgrowth, accumulates in the axonal growth cone and subsequently localizes throughout the axon (By similarity).
Partially localizes to dendrites in mature neurons (By similarity).
Colocalizes with neurofilament (NF)-rich inclusions in spinal cord and brain neurons of patients with amyotrophic lateral sclerosis (ALS) (PubMed:14692697).

PTM

Palmitoylated. Probably depalmitoylated by ABHD17A, ABHD17B and ABHD17C. During neuronal polarization, palmitoylation and depalmitoylation cycles regulate MAP6 shuttling between secretory vesicles and microtubules, and its polarized distribution in the axon.