Mouse Anti-MAP6 Recombinant Antibody (CBXS-4314) (CBMAB-S1559-CQ)

Name: Mouse Anti-MAP6 Recombinant Antibody (CBXS-4314)
SKU: CBMAB-S1559-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-4314

Application

WB, IP, IF

Specificity

Mouse, Rat, Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Microtubule Associated Protein 6

Introduction

This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene.

Entrez Gene ID

Human	4135
Mouse	17760
Rat	29457

UniProt ID

Human	Q96JE9
Mouse	Q7TSJ2
Rat	Q63560

Alternative Names

Microtubule Associated Protein 6; Stable Tubule-Only Polypeptide; MAP-6; STOP; Microtubule-Associated Protein 6; CTD-2530H12.7;

Function

Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity).
Specifically has microtubule cold stabilizing activity (By similarity).
Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581).
Regulates KIF5A-mediated axonal cargo transport (By similarity).
Regulates axonal growth during neuron polarization (By similarity).

Biological Process

Cytoskeleton-dependent intracellular transportManual Assertion Based On ExperimentIBA:GO_Central
Dendrite morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Lysosome localizationManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule cytoskeleton organizationIEA:InterPro
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of microtubule cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm, cytoskeleton
Golgi apparatus
Cell projection, axon
Cell projection, dendrite
Cytoplasmic vesicle, secretory vesicle membrane
Localizes predominantly in the proximal part of the axon (By similarity).
Preferentially is concentrated on a portion of the microtubule polymer in which tubulin is modified by detyrosination and acetylation and is also resistant to depolymerization induced by both nocodazole and cold (By similarity).
In unpolarized neurons, localizes to the Golgi and to secretory vesicles accumulating transiently at the tips of a subset of neurites (By similarity).
Following neuronal polarization and during axon outgrowth, accumulates in the axonal growth cone and subsequently localizes throughout the axon (By similarity).
Partially localizes to dendrites in mature neurons (By similarity).
Colocalizes with neurofilament (NF)-rich inclusions in spinal cord and brain neurons of patients with amyotrophic lateral sclerosis (ALS) (PubMed:14692697).

PTM

Palmitoylated. Probably depalmitoylated by ABHD17A, ABHD17B and ABHD17C. During neuronal polarization, palmitoylation and depalmitoylation cycles regulate MAP6 shuttling between secretory vesicles and microtubules, and its polarized distribution in the axon.

Cuveillier, C. (2022). MAP6: a multifunctional regulator of the cytoskeleton (Doctoral dissertation, Université Grenoble Alpes [2020-....]).

Cuveillier, C., Boulan, B., Ravanello, C., Denarier, E., Deloulme, J. C., Gory-Fauré, S., ... & Andrieux, A. (2021). Beyond neuronal microtubule stabilization: MAP6 and CRMPS, two converging stories. Frontiers in Molecular Neuroscience, 14, 665693.

Cuveillier, C., Delaroche, J., Seggio, M., Gory-Fauré, S., Bosc, C., Denarier, E., ... & Delphin, C. (2020). MAP6 is an intraluminal protein that induces neuronal microtubules to coil. Science Advances, 6(14), eaaz4344.

Ma, L., Song, J., Sun, X., Ding, W., Fan, K., Qi, M., ... & Zhang, W. (2019). Role of microtubule-associated protein 6 glycosylated with Gal-(β-1, 3)-GalNAc in Parkinson's disease. Aging (Albany NY), 11(13), 4597.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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