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MAPK3

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Full Name
Mitogen-Activated Protein Kinase 3
Function
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIAC F4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.
Biological Process
Apoptotic processIEA:UniProtKB-KW
Bergmann glial cell differentiationIEA:Ensembl
BMP signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Cardiac neural crest cell development involved in heart developmentIEA:Ensembl
Cartilage developmentIEA:Ensembl
Caveolin-mediated endocytosisManual Assertion Based On ExperimentTAS:UniProtKB
Cell cycleIEA:UniProtKB-KW
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to amino acid starvationManual Assertion Based On ExperimentIDA:CAFA
Cellular response to cadmium ionManual Assertion Based On ExperimentIMP:CAFA
Cellular response to dopamineManual Assertion Based On ExperimentIMP:CAFA
Cellular response to mechanical stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Cellular response to reactive oxygen speciesManual Assertion Based On ExperimentIMP:CAFA
Cellular response to tumor necrosis factorIEA:Ensembl
DNA damage induced protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
ERK1 and ERK2 cascadeIEA:Ensembl
Face developmentIEA:Ensembl
Interleukin-1-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Lipopolysaccharide-mediated signaling pathwayIEA:Ensembl
Lung morphogenesisIEA:Ensembl
MAPK cascade1 PublicationNAS:BHF-UCL
Negative regulation of apolipoprotein bindingIEA:Ensembl
Outer ear morphogenesisIEA:Ensembl
Peptidyl-tyrosine autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
PhosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cyclase activityManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:CAFA
Positive regulation of histone acetylationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of histone phosphorylationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of macrophage chemotaxisManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of macrophage proliferationManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of telomerase activityManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of telomere cappingManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of telomere maintenance via telomeraseManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of xenophagyIEA:Ensembl
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cellular pHIEA:Ensembl
Regulation of cytoskeleton organizationManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of DNA-binding transcription factor activityIEA:Ensembl
Regulation of early endosome to late endosome transportManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of Golgi inheritanceManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of ossificationIEA:Ensembl
Regulation of stress-activated MAPK cascadeManual Assertion Based On ExperimentTAS:UniProtKB
Response to epidermal growth factorManual Assertion Based On ExperimentIDA:UniProtKB
Response to exogenous dsRNAIEA:Ensembl
Sensory perception of painIEA:Ensembl
Stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:CAFA
Thymus developmentIEA:Ensembl
Thyroid gland developmentIEA:Ensembl
Trachea formationIEA:Ensembl
Transcription, DNA-templatedIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Membrane, caveola
Cell junction, focal adhesion
Autophosphorylation at Thr-207 promotes nuclear localization (PubMed:19060905).
PEA15-binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm (By similarity).
PTM
Phosphorylated upon KIT and FLT3 signaling (By similarity).
Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-204.

Anti-MAPK3 antibodies

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Target: MAPK3
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBFYE-1532
Application*: WB, IP, IF, P, E
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey
Clone: CBFYE-1531
Application*: WB, IH, IF
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Yeast
Clone: CBFYE-1530
Application*: IF, P, WB
Target: MAPK3
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBFYE-1527
Application*: WB, IF
Target: MAPK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: Y71
Application*: WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: E19
Application*: IP, WB
Target: MAPK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: Y72
Application*: IP, F, P, IC, IF, WB
Target: MAPK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EP4967
Application*: P, F, IC, IF, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: 1E5
Application*: E, P, F, IC, IF, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBFYM-1619
Application*: E, IP, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-1618
Application*: E, IC, IF, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1617
Application*: E, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-1616
Application*: CI, IF
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1615
Application*: IP, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1614
Application*: E, F, IC, IF, IH, WB
Target: MAPK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Hamster, Monkey, Mink, Fruit fly, Zebrafish, Cattle, Dog, Pig, C. elegans, Chicken
Clone: CBFYM-0784
Application*: WB, IP, P, IF, F
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-0783
Application*: E, IF, IH, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBFYM-0564
Application*: E, IP, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBFYM-0125
Application*: WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human, Mouse, Rat
Clone: CBFYM-0042
Application*: C, E, IF, IP, WB
Target: MAPK3
Host: Mouse
Specificity: Human
Clone: CBFYH-2636
Application*: WB, IC, P, C, E
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Chicken, Dog, Frog, Human, Mouse
Clone: CBFYE-1535
Application*: WB, IF, IH, IP
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rabbit, Human
Clone: CBFYE-1528
Application*: WB, E, P, IF
Target: MAPK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-1526
Application*: F
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Hamster, Human, Mink, Mouse, Pig, Rat, Zebrafish
Clone: CBFYE-1525
Application*: WB
Target: MAPK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYE-1524
Application*: E, WB, IP
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C9
Application*: E, IC, IF, P, IP, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYE-1523
Application*: WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBFYE-1522
Application*: F, IC, IF, IH, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Dog, Chicken, Human, Mouse, Rat, Frog
Clone: CBFYE-1521
Application*: IC, IH, IP, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: CBFYE-1520
Application*: E, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBFYE-1519
Application*: WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-1518
Application*: WB, IH, IC
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBFYE-1517
Application*: WB, IH
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Dog
Clone: CBFYE-1516
Application*: E, IC, IH, IP, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0257
Application*: IC, P, IP, WB
Target: MAPK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBFYE-0140
Application*: WB, IP, F, IF
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYE-0074
Application*: WB, E, IF
Target: MAPK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Cattle, C. elegans, Dog, Chicken, Fruit fly, Hamster, Human, Mink, Mouse, Pig, Rat, Zebrafish
Clone: K.913.4
Application*: F, IC, IF, P, IP, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 12D11
Application*: WB, CI, IH, IF, P
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 2C6-A12-G8
Application*: WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 5AD13MA
Application*: IC, IF, P, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Dog, Human, Mouse, Rat
Clone: ERK-6B11
Application*: E, IP, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Dog, Human, Mouse, Rat
Clone: ERK-7D8
Application*: E, GS, IC, IF, P, IP, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Hamster, Mouse, Rat
Clone: 3A22(E10)
Application*: E, FC, IC, IP, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Dog, Rat
Clone: 6D69
Application*: E, IP, WB
Target: MAPK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-155
Application*: E, WB, IH, IF
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1B1
Application*: WB, E
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 3D6
Application*: WB, E
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 5E9
Application*: IHC
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 4G11
Application*: IHC
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 1C11
Application*: IHC
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: E31R
Application*: WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 7D3
Application*: IHC, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CAP723
Application*: WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 621
Application*: ELISA, IF, IHC, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP945
Application*: WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: A1006
Application*: Dot blot, ELISA, IF, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: A1007
Application*: IP, WB
Target: MAPK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1008
Application*: FC, ICC, IF, IP, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A1009
Application*: WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1010
Application*: IF, IHC, IP, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 6F1-8G10-4H2
Application*: F, WB
Target: MAPK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 4A4-G4-F6
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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