MASP2

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Full Name
Mannan Binding Lectin Serine Peptidase 2
Function
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
Biological Process
Cell surface pattern recognition receptor signaling pathway Source: ComplexPortal
Complement activation, classical pathway Source: UniProtKB-KW
Complement activation, lectin pathway Source: ComplexPortal
Positive regulation of opsonization Source: ComplexPortal
Proteolysis Source: ComplexPortal
Cellular Location
Secreted
Involvement in disease
MASP2 deficiency (MASPD):
A disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease.
PTM
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Activated by cleavage after Arg-444. The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cleavage.
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Anti-MASP2 antibodies

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Mouse Anti-MASP2 Recombinant Antibody (A1014) (CBMAB-AP4357LY)

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Target: MASP2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: A1014
Application*: ICC, IHC, IP, WB
Datasheet SDS

Recombinant Rat Anti-MASP2 Antibody (CBHb249) (CBMAB-Hb726-LY)

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Target: MASP2
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb249
Application*: Immuno assays, WB
Datasheet SDS

Rat Anti-MASP2 Recombinant Antibody (CBFYM-1746) (CBMAB-M1914-FY)

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Target: MASP2
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1746
Application*: IA, WB
Datasheet SDS

Mouse Anti-MASP2 Recombinant Antibody (CBFYM-1745) (CBMAB-M1913-FY)

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Target: MASP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-1745
Application*: E
Datasheet SDS

Mouse Anti-MASP2 Recombinant Antibody (CBFYM-1744) (CBMAB-M1912-FY)

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Target: MASP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-1744
Application*: WB
Datasheet SDS

Mouse Anti-MASP2 (AA 170-287) Recombinant Antibody (CBFYM-0520) (CBMAB-M0648-FY)

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Target: MASP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-0520
Application*: E, IC, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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