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MED4

This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Full Name

MED4

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Biological Process

Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription elongation from RNA polymerase II promoter Source: ComplexPortal
Positive regulation of transcription initiation from RNA polymerase II promoter Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
RNA polymerase II preinitiation complex assembly Source: ComplexPortal
Transcription by RNA polymerase II Source: UniProtKB

Cellular Location

Nucleus

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Anti-MED4 antibodies

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Mouse Anti-MED4 Antibody (1A6) (CBMAB-0650-YC)

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Target: MED4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1A6

Application*: IP, M

Mouse Anti-MED4 Recombinant Antibody (2B10) (CBMAB-A5377-LY)

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Target: MED4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2B10

Application*: WB, E

Mouse Anti-MED4 (AA 1-270) Recombinant Antibody (CBFYM-2011) (CBMAB-M2189-FY)

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Target: MED4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-2011

Application*: E, IF, WB

Mouse Anti-MED4 Recombinant Antibody (CBFYM-0616) (CBMAB-M0750-FY)

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Target: MED4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-0616

Application*: E, WB

Rabbit Anti-MED4 Recombinant Antibody (CBFYM-0316) (CBMAB-M0381-FY)

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Target: MED4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human, Fruit fly

Clone: CBFYM-0316

Application*: WB, IP, P, IF

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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