MEOX1

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]
Full Name
mesenchyme homeobox 1
Function
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994).

Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
Biological Process
Hematopoietic stem cell differentiation Source: UniProtKB
Multicellular organism development Source: ProtInc
Regulation of transcription by RNA polymerase II Source: GO_Central
Sclerotome development Source: UniProtKB
Somite development Source: UniProtKB
Somite specification Source: Ensembl
Cellular Location
Cytoplasm
Nucleus
Note: Localizes predominantly in the nucleus.
Involvement in disease
Klippel-Feil syndrome 2, autosomal recessive (KFS2):
A skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement.
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Anti-MEOX1 antibodies

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Mouse Anti-MEOX1 Recombinant Antibody (1A12) (CBMAB-A5423-LY)

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Target: MEOX1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1A12
Application*: IF, E
Datasheet SDS

Mouse Anti-MEOX1 Recombinant Antibody (4E10) (CBMAB-A5420-LY)

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Target: MEOX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4E10
Application*: WB, E
Datasheet SDS

Mouse Anti-MEOX1 (AA 165-252) Recombinant Antibody (CBFYM-2070) (CBMAB-M2251-FY)

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Target: MEOX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2070
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-MEOX1 (AA 82-170) Recombinant Antibody (CBFYM-2069) (CBMAB-M2250-FY)

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Target: MEOX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2069
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-MEOX1 (AA 165-253) Recombinant Antibody (CBFYM-2068) (CBMAB-M2249-FY)

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Target: MEOX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2068
Application*: E, WB
Datasheet SDS

Mouse Anti-MEOX1 Recombinant Antibody (CBFYM-2067) (CBMAB-M2248-FY)

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Target: MEOX1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2067
Application*: WB
Datasheet SDS

Mouse Anti-MEOX1 Recombinant Antibody (CBFYM-2066) (CBMAB-M2247-FY)

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Target: MEOX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2066
Application*: WB, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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