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Mouse Anti-MEOX1 (AA 165-252) Recombinant Antibody (CBFYM-2070) (CBMAB-M2251-FY)

This product is mouse antibody that recognizes MEOX1. The antibody CBFYM-2070 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all MEOX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2070
Antibody Isotype
IgG2a, k
Application
ELISA, IF, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa165-252 from human MEOX1 (NP_004518.1) with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 165-252

Target

Full Name
mesenchyme homeobox 1
Introduction
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described.
Entrez Gene ID
4222
UniProt ID
P50221
Alternative Names
Mesenchyme Homeobox 1; MOX1; Mesenchyme Homeo Box 1; Homeobox Protein MOX-1; KFS2
Function
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994).

Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
Biological Process
Hematopoietic stem cell differentiation Source: UniProtKB
Multicellular organism development Source: ProtInc
Regulation of transcription by RNA polymerase II Source: GO_Central
Sclerotome development Source: UniProtKB
Somite development Source: UniProtKB
Somite specification Source: Ensembl
Cellular Location
Cytoplasm
Nucleus
Note: Localizes predominantly in the nucleus.
Involvement in disease
Klippel-Feil syndrome 2, autosomal recessive (KFS2):
A skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement.

Zeng, G., Liu, X., Su, X., Wang, Y., Liu, B., Zhou, H., ... & Li, F. (2023). The role of MEOX1 in non-neoplastic and neoplastic diseases. Biomedicine & Pharmacotherapy, 158, 114068.

Baßler, K., Schmidleithner, L., Shakiba, M. H., Elmzzahi, T., Köhne, M., Floess, S., ... & Beyer, M. (2023). Identification of the novel FOXP3-dependent Treg cell transcription factor MEOX1 by high-dimensional analysis of human CD4+ T cells. Frontiers in Immunology, 14.

Xiao, X., Rui, B., Rui, H., Ju, M., & Hongtao, L. (2022). MEOX1 suppresses the progression of lung cancer cells by inhibiting the cell‐cycle checkpoint gene CCNB1. Environmental Toxicology, 37(3), 504-513.

Yatagai, Y., Oshima, H., Sakamoto, T., Shigemasa, R., Kitazawa, H., Hyodo, K., ... & Hizawa, N. (2021). Expression quantitative trait loci for ETV4 and MEOX1 are associated with adult asthma in Japanese populations. Scientific Reports, 11(1), 18791.

Schumacher, D., Peisker, F., & Kramann, R. (2021). MEOX1: a novel druggable target that orchestrates the activation of fibroblasts in cardiac fibrosis. Signal Transduction and Targeted Therapy, 6(1), 440.

Wu, Y., Li, Y. J., Shi, L. L., Liu, Y., Wang, Y., Bao, X., ... & Zhang, J. X. (2021). Spatio-temporal model of Meox1 expression control involvement of Sca-1-positive stem cells in neointima formation through the synergistic effect of Rho/CDC42 and SDF-1α/CXCR4. Stem Cell Research & Therapy, 12(1), 1-15.

Wang, W., Fang, Q., Zhang, Z., Wang, D., Wu, L., & Wang, Y. (2020). PPARα ameliorates doxorubicin-induced cardiotoxicity by reducing mitochondria-dependent apoptosis via regulating MEOX1. Frontiers in Pharmacology, 11, 528267.

Gasparyan, M., Lo, M. C., Jiang, H., Lin, C. C., & Sun, D. (2020). Combined p53-and PTEN-deficiency activates expression of mesenchyme homeobox 1 (MEOX1) required for growth of triple-negative breast cancer. Journal of Biological Chemistry, 295(34), 12188-12202.

Sun, L., Yuan, H., Burnett, J., Gasparyan, M., Zhang, Y., Zhang, F., ... & Sun, D. (2019). MEOX1 promotes tumor progression and predicts poor prognosis in human non-small-cell lung cancer. International Journal of Medical Sciences, 16(1), 68.

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For research use only. Not intended for any clinical use.

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